PMID- 7637092
OWN - NLM
STAT- MEDLINE
DCOM- 19950911
LR  - 20071114
IS  - 0022-5347 (Print)
IS  - 0022-5347 (Linking)
VI  - 154
IP  - 3
DP  - 1995 Sep
TI  - Selective type IV collagen defects in the urothelial basement membrane in 
      interstitial cystitis.
PG  - 1222-6
AB  - PURPOSE: The study sought to identify changes in the urothelial basement membrane 
      (UBM) associated with interstitial cystitis (IC). MATERIALS AND METHODS: 
      Immunohistochemical assessment of bladder biopsies from IC patients and controls 
      was compared with clinical and histologic findings. RESULTS: Selective decreases 
      or loss of type IV collagen staining, but not laminin, were found in the UBM of 5 
      of 11 IC patients with no change in type IV collagen staining of other bladder 
      wall sites. CONCLUSIONS: The loss of type IV collagen may represent a primary or 
      secondary event and could alter the UBM's role in permeability, thereby 
      contributing to the pathogenesis of IC in the subset of IC patients exhibiting 
      this change.
FAU - Wilson, C B
AU  - Wilson CB
AD  - Department of Immunology, Scripps Research Institute, La Jolla, California 
      92037-1093, USA.
FAU - Leopard, J
AU  - Leopard J
FAU - Nakamura, R M
AU  - Nakamura RM
FAU - Cheresh, D A
AU  - Cheresh DA
FAU - Stein, P C
AU  - Stein PC
FAU - Parsons, C L
AU  - Parsons CL
LA  - eng
GR  - DK42717/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Urol
JT  - The Journal of urology
JID - 0376374
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Basement Membrane/*chemistry/pathology
MH  - Collagen/*deficiency
MH  - Cystitis/*metabolism/pathology
MH  - Epithelium/chemistry/pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Urinary Bladder/*chemistry/pathology
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - S0022-5347(01)67035-6 [pii]
PST - ppublish
SO  - J Urol. 1995 Sep;154(3):1222-6.