PMID- 7637154
OWN - NLM
STAT- MEDLINE
DCOM- 19950913
LR  - 20181130
IS  - 0021-4892 (Print)
IS  - 0021-4892 (Linking)
VI  - 44
IP  - 6
DP  - 1995 Jun
TI  - [Milrinone suppresses TNF-alpha and IL-1 beta release in mouse peritoneal 
      macrophages].
PG  - 800-4
AB  - Tumor necrosis factor-alpha (TNF-alpha) exerts a wide spectrum of biological 
      activities and contributes to the pathophysiology of septic shock. We studied 
      whether milrinone suppresses TNF-alpha and IL-1 beta releases from mouse 
      peritoneal macrophages. Mouse peritoneal macrophages were stimulated for 18 hr 
      with lipopolysaccharide and different doses of milrinone. TNF-alpha release was 
      suppressed in a dose-dependent fashion with milrinone, reaching half-maximal 
      inhibition at 30 microM. Release of IL-1 beta was not suppressed with 25 microM 
      of milrinone, but it was suppressed with 250 microM of milrinone. We conclude 
      that TNF-alpha release is suppressed by therapeutically administered milrinone.
FAU - Masaki, Y
AU  - Masaki Y
AD  - Department of Anesthesiology, Akita University School of Medicine.
FAU - Sato, W
AU  - Sato W
FAU - Kayaba, M
AU  - Kayaba M
FAU - Enzan, K
AU  - Enzan K
FAU - Suzuki, M
AU  - Suzuki M
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Masui
JT  - Masui. The Japanese journal of anesthesiology
JID - 0413707
RN  - 0 (Interleukin-1)
RN  - 0 (Pyridones)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - JU9YAX04C7 (Milrinone)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Dose-Response Relationship, Drug
MH  - Interleukin-1/*metabolism
MH  - Macrophages, Peritoneal/*metabolism
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Milrinone
MH  - Pyridones/*pharmacology
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 1995/06/01 00:00
MHDA- 1995/06/01 00:01
CRDT- 1995/06/01 00:00
PHST- 1995/06/01 00:00 [pubmed]
PHST- 1995/06/01 00:01 [medline]
PHST- 1995/06/01 00:00 [entrez]
PST - ppublish
SO  - Masui. 1995 Jun;44(6):800-4.