PMID- 7638860 OWN - NLM STAT- MEDLINE DCOM- 19950914 LR - 20190825 IS - 0001-2815 (Print) IS - 0001-2815 (Linking) VI - 45 IP - 4 DP - 1995 Apr TI - HLA class II typing and idiopathic IgA nephropathy (IgAN): DQB1*0301, a possible marker of unfavorable outcome. PG - 246-9 AB - Previous studies have reported associations between HLA antigens and Idiopathic IgA Nephropathy (IgAN). Nevertheless most of the studies were performed by serology. Thus we decided to perform the HLA class II typing of 58 patients by molecular biology techniques. We report a small increase of DRB1*04. But the main result of our study is the identification of a strong association between HLA DQB1*0301 and IgAN patients with an unfavorable outcome. FAU - Raguenes, O AU - Raguenes O AD - Centre de Biogenetique, Centre Departemental de Transfusion Sanguine, Brest, France. FAU - Mercier, B AU - Mercier B FAU - Cledes, J AU - Cledes J FAU - Whebe, B AU - Whebe B FAU - Ferec, C AU - Ferec C LA - eng PT - Journal Article PL - England TA - Tissue Antigens JT - Tissue antigens JID - 0331072 RN - 0 (Genetic Markers) RN - 0 (HLA-DP Antigens) RN - 0 (HLA-DP beta-Chains) RN - 0 (HLA-DPB1 antigen) RN - 0 (HLA-DQ Antigens) RN - 0 (HLA-DQ alpha-Chains) RN - 0 (HLA-DQ beta-Chains) RN - 0 (HLA-DQA1 antigen) RN - 0 (HLA-DQB1 antigen) RN - 0 (HLA-DR Antigens) RN - 0 (HLA-DRB1 Chains) SB - IM MH - Gene Frequency MH - Genetic Markers MH - Glomerulonephritis, IGA/genetics/*immunology MH - HLA-DP Antigens MH - HLA-DP beta-Chains MH - HLA-DQ Antigens/*analysis MH - HLA-DQ alpha-Chains MH - HLA-DQ beta-Chains MH - HLA-DR Antigens MH - HLA-DRB1 Chains MH - Histocompatibility Testing MH - Humans MH - Prognosis EDAT- 1995/04/01 00:00 MHDA- 1995/04/01 00:01 CRDT- 1995/04/01 00:00 PHST- 1995/04/01 00:00 [pubmed] PHST- 1995/04/01 00:01 [medline] PHST- 1995/04/01 00:00 [entrez] AID - 10.1111/j.1399-0039.1995.tb02447.x [doi] PST - ppublish SO - Tissue Antigens. 1995 Apr;45(4):246-9. doi: 10.1111/j.1399-0039.1995.tb02447.x.