PMID- 7639798
OWN - NLM
STAT- MEDLINE
DCOM- 19950914
LR  - 20190718
IS  - 0004-3591 (Print)
IS  - 0004-3591 (Linking)
VI  - 38
IP  - 8
DP  - 1995 Aug
TI  - Levels of circulating collagenase, stromelysin-1, and tissue inhibitor of matrix 
      metalloproteinases 1 in patients with rheumatoid arthritis. Relationship to serum 
      levels of antigenic keratan sulfate and systemic parameters of inflammation.
PG  - 1031-9
AB  - OBJECTIVE: To measure serum levels of matrix metalloproteinase-1 (MMP-1), matrix 
      metalloproteinase-3 (MMP-3), and tissue inhibitor of MMP-1 (TIMP-1) in patients 
      with rheumatoid arthritis (RA) and in age-matched control subjects, and to 
      determine how these correlate with serum levels of antigenic keratan sulfate (KS) 
      and other biochemical and clinical indicators of disease activity. METHODS: 
      Immunoassays were used to measure levels of MMP-1, MMP-3, TIMP-1, and antigenic 
      KS. Radiologic and functional joint scores were based upon Steinbrocker's 
      criteria. Erythrocyte sedimentation rates (ESR) and levels of C-reactive proteins 
      (CRP) were measured. RESULTS: In RA patients, levels of MMP-3 and TIMP-1 were 
      significantly increased, and strongly correlated with the ESR and CRP levels but 
      not with radiologic or functional joint scores. Levels of antigenic KS were 
      significantly lower in RA patients and correlated negatively with systemic 
      parameters of inflammation and serum levels of TIMP-1. CONCLUSIONS: The increase 
      in serum levels of MMP-3 and TIMP-1 appears to reflect systemic inflammation in 
      RA. The inverse correlation between serum levels of TIMP-1 and antigenic KS 
      suggests that an upregulation of TIMP-1 synthesis might be responsible for the 
      apparent suppression of cartilage aggrecan catabolism in patients with severe 
      inflammatory changes.
FAU - Manicourt, D H
AU  - Manicourt DH
AD  - Saint Luc University Hospital, University of Louvain, Brussels, Belgium.
FAU - Fujimoto, N
AU  - Fujimoto N
FAU - Obata, K
AU  - Obata K
FAU - Thonar, E J
AU  - Thonar EJ
LA  - eng
GR  - AG-04736/AG/NIA NIH HHS/United States
GR  - I-P50-AR-39239/AR/NIAMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Arthritis Rheum
JT  - Arthritis and rheumatism
JID - 0370605
RN  - 0 (Antigens)
RN  - 0 (Biomarkers)
RN  - 0 (Glycoproteins)
RN  - 0 (Matrix Metalloproteinase Inhibitors)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Protease Inhibitors)
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 9056-36-4 (Keratan Sulfate)
RN  - EC 3.4.24.- (Collagenases)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.7 (Matrix Metalloproteinase 1)
SB  - IM
CIN - Arthritis Rheum. 1996 May;39(5):884-6. PMID: 8639190
MH  - Adult
MH  - Aged
MH  - Antigens/blood
MH  - Arthritis, Rheumatoid/*blood/enzymology/immunology
MH  - Arthrography
MH  - Biomarkers
MH  - Blood Sedimentation
MH  - C-Reactive Protein/analysis
MH  - Collagenases/blood
MH  - Erythrocyte Count
MH  - Female
MH  - Glycoproteins/*blood
MH  - Humans
MH  - Inflammation/blood
MH  - Keratan Sulfate/blood/immunology
MH  - Kidney Function Tests
MH  - Liver Function Tests
MH  - Male
MH  - Matrix Metalloproteinase 1
MH  - Matrix Metalloproteinase 3
MH  - Matrix Metalloproteinase Inhibitors
MH  - Metalloendopeptidases/*blood
MH  - Middle Aged
MH  - Neoplasm Proteins/blood
MH  - Protease Inhibitors/blood
MH  - Tissue Inhibitor of Metalloproteinases
EDAT- 1995/08/01 00:00
MHDA- 1995/08/01 00:01
CRDT- 1995/08/01 00:00
PHST- 1995/08/01 00:00 [pubmed]
PHST- 1995/08/01 00:01 [medline]
PHST- 1995/08/01 00:00 [entrez]
AID - 10.1002/art.1780380803 [doi]
PST - ppublish
SO  - Arthritis Rheum. 1995 Aug;38(8):1031-9. doi: 10.1002/art.1780380803.