PMID- 7643615
OWN - NLM
STAT- MEDLINE
DCOM- 19950920
LR  - 20141120
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 9
IP  - 8
DP  - 1995 Aug
TI  - Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in 
      acute leukemia and localization to human chromosome 1q31.
PG  - 1291-8
AB  - A basic helix-loop-helix phosphoprotein gene, G0S8, was recently isolated by 
      differential screening of cDNA from human blood mononuclear cells stimulated with 
      a T cell mitogen and cycloheximide. In this study, G0S8 expression was examined 
      in normal and malignant hematopoietic cells by Northern blot analysis and reverse 
      transcription-polymerase chain reaction (RT-PCR). G0S8 expression was observed in 
      most fresh samples of acute myelogenous leukemia (AML) (28/30) and most cases of 
      adult acute lymphoblastic leukemia (ALL) (9/11) regardless of clinical 
      classification. G0S8 mRNA was also detected in all cases tested of chronic 
      myelogenous leukemia (CML) in blast crisis. However, G0S8 expression was not 
      detected in CML patients in chronic phase, nor in normal bone marrow or other 
      hematopoietic cells. G0S8 has been mapped using fluorescence in situ 
      hybridization (FISH) to human chromosome 1q31, the same site reported for the B 
      cell homolog BL34/1R20 and within a region implicated in the development of 
      hematological malignancies. The consistent observation of G0S8 mRNA in patient 
      samples of acute leukemia suggests that G0S8 expression may either play a role in 
      leukemogenesis or represent a common consequence of dysregulated growth.
FAU - Wu, H K
AU  - Wu HK
AD  - Department of Medicine, University of Toronto, ON, Canada.
FAU - Heng, H H
AU  - Heng HH
FAU - Shi, X M
AU  - Shi XM
FAU - Forsdyke, D R
AU  - Forsdyke DR
FAU - Tsui, L C
AU  - Tsui LC
FAU - Mak, T W
AU  - Mak TW
FAU - Minden, M D
AU  - Minden MD
FAU - Siderovski, D P
AU  - Siderovski DP
LA  - eng
SI  - GENBANK/L13391
SI  - GENBANK/L13463
SI  - GENBANK/L24395
SI  - GENBANK/M18105
SI  - GENBANK/S59049
SI  - GENBANK/X73427
SI  - GENBANK/Z32679
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (DNA Primers)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (RGS Proteins)
RN  - 0 (RGS2 protein, human)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Neoplasm)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cell Cycle
MH  - Chromosomes, Human, Pair 1
MH  - DNA Primers/chemistry
MH  - DNA-Binding Proteins/*genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Helix-Loop-Helix Motifs
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - In Vitro Techniques
MH  - Molecular Sequence Data
MH  - Phosphoproteins/*genetics
MH  - *RGS Proteins
MH  - RNA, Messenger/genetics
MH  - RNA, Neoplasm/genetics
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Tumor Cells, Cultured
EDAT- 1995/08/01 00:00
MHDA- 1995/08/01 00:01
CRDT- 1995/08/01 00:00
PHST- 1995/08/01 00:00 [pubmed]
PHST- 1995/08/01 00:01 [medline]
PHST- 1995/08/01 00:00 [entrez]
PST - ppublish
SO  - Leukemia. 1995 Aug;9(8):1291-8.