PMID- 7646814
OWN - NLM
STAT- MEDLINE
DCOM- 19950925
LR  - 20171116
IS  - 1044-5498 (Print)
IS  - 1044-5498 (Linking)
VI  - 14
IP  - 8
DP  - 1995 Aug
TI  - Cloning, chromosomal localization, and RNA expression of a human beta chemokine 
      receptor-like gene.
PG  - 673-80
AB  - A human cDNA encoding a putative G protein-coupled receptor designated chemokine 
      beta receptor-like 1 (CMKBRL1) was isolated from an eosinophilic leukemia 
      library. Its deduced sequence is approximately 40% identical to previously cloned 
      receptors for the beta chemokines macrophage inflammatory protein-1 alpha (MIP-1 
      alpha), RANTES, and monocyte chemoattractant protein-1 (MCP-1), which are 
      chemoattractants for blood leukocytes, and is 83% identical to the product of the 
      orphan rat cDNA RBS 11. Like the MIP-1 alpha/RANTES receptor, CMK-BRL1 is encoded 
      by a small, single-copy gene that maps to chromosome 3p21 and is expressed in 
      leukocytes. However, two screening assays with a broad panel of chemokines failed 
      to identify its ligand. CMKBRL1 mRNA was detectable by Northern blot 
      hybridization in neutrophils and monocytes, but not eosinophils, and was also 
      found in eight solid organs that were tested with particularly high expression in 
      brain. The RNA distribution of the known beta chemokine receptors was overlapping 
      but distinct from that of CMKBRL1. MIP-1 alpha/RANTES receptor mRNA was 
      detectable in neutrophils, monocytes, eosinophils, and in all eight solid organs 
      tested, with particularly high expression in placenta, lung, and liver. MCP-1 
      receptor mRNA was found in monocytes, lung, liver, and pancreas. These results 
      suggest that the ligand for the putative CMKBRL1 receptor is a beta chemokine 
      that targets both neutrophils and monocytes. Moreover, the RNA distributions 
      suggest that CMKBRL1, the MIP-1 alpha/RANTES receptor, and the MCP-1 receptor may 
      have both overlapping and distinct biological roles.
FAU - Combadiere, C
AU  - Combadiere C
AD  - Laboratory of Host Defenses, National Institute of Allergy and Infectious 
      Diseases, Bethesda, MD 20892, USA.
FAU - Ahuja, S K
AU  - Ahuja SK
FAU - Murphy, P M
AU  - Murphy PM
LA  - eng
SI  - GENBANK/U28934
PT  - Journal Article
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (CX3C Chemokine Receptor 1)
RN  - 0 (CX3CR1 protein, human)
RN  - 0 (DNA, Complementary)
RN  - 0 (Ligands)
RN  - 0 (Membrane Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Receptors, Cytokine)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - CX3C Chemokine Receptor 1
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 3
MH  - Cloning, Molecular
MH  - DNA, Complementary/genetics
MH  - Gene Dosage
MH  - Genes/*genetics
MH  - Humans
MH  - Hypereosinophilic Syndrome
MH  - Ligands
MH  - Membrane Proteins/*genetics
MH  - Molecular Sequence Data
MH  - Monocytes/*chemistry
MH  - Neutrophils/*chemistry
MH  - Organ Specificity
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - *Receptors, Chemokine
MH  - Receptors, Cytokine/*genetics
MH  - Sequence Analysis, DNA
MH  - Sequence Homology, Amino Acid
EDAT- 1995/08/01 00:00
MHDA- 1995/08/01 00:01
CRDT- 1995/08/01 00:00
PHST- 1995/08/01 00:00 [pubmed]
PHST- 1995/08/01 00:01 [medline]
PHST- 1995/08/01 00:00 [entrez]
AID - 10.1089/dna.1995.14.673 [doi]
PST - ppublish
SO  - DNA Cell Biol. 1995 Aug;14(8):673-80. doi: 10.1089/dna.1995.14.673.