PMID- 7647011
OWN - NLM
STAT- MEDLINE
DCOM- 19950925
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 90
IP  - 3
DP  - 1995 Jul
TI  - Monoclonal gammopathy of undetermined significance: chromosome changes are a 
      common finding within bone marrow plasma cells.
PG  - 693-6
AB  - We used two indirect approaches [image analysis (Feulgen staining) and 
      fluorescence in situ hybridization (FISH)] to study bone marrow plasma cells 
      (BMPC) in 28 patients fulfilling criteria for MGUS. 61% of patients were found to 
      be aneuploid after image analysis: three were hypodiploid and 14 were 
      hyperdiploid. 12/14 hyperdiploid patients also revealed abnormalities after FISH: 
      12-72% of BMPC exhibited trisomy for at least one of chromosomes 3, 7, 9 and 11. 
      These latter chromosomes are the four chromosomes most frequently implicated (in 
      the shape of trisomy) in MM, confirming the tight relationship between both 
      conditions. After a median follow-up of 19 months (12-41 months) no patient 
      developed overt MM. Also, we failed to find any relationship between currently 
      available biological parameters and DNA findings. As literature data give a 
      transformation rate of 20-30% after a follow-up of 20-35 years, it is worth 
      presuming that some aneuploid patients will evolve to MM, whereas others (also 
      with aneuploid bone marrow plasma cells) will never develop cancer. Our findings 
      indicate that numeric abnormalities, as they are shared both by MGUS and MM 
      patients, are certainly an additional or a prerequisite event, but are not 
      related to an overt disease. They also emphasize the importance of cytogenetic 
      study in the pathophysiology of MGUS.
FAU - Zandecki, M
AU  - Zandecki M
AD  - Laboratoire d'Hematologie, Hopital Calmette, Lille, France.
FAU - Obein, V
AU  - Obein V
FAU - Bernardi, F
AU  - Bernardi F
FAU - Soenen, V
AU  - Soenen V
FAU - Flactif, M
AU  - Flactif M
FAU - Lai, J L
AU  - Lai JL
FAU - Francois, M
AU  - Francois M
FAU - Facon, T
AU  - Facon T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Aneuploidy
MH  - Bone Marrow/*ultrastructure
MH  - Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 3
MH  - Chromosomes, Human, Pair 7
MH  - Chromosomes, Human, Pair 9
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Interphase
MH  - Middle Aged
MH  - Paraproteinemias/*genetics
MH  - Plasma Cells/*ultrastructure
MH  - Trisomy
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
AID - 10.1111/j.1365-2141.1995.tb05602.x [doi]
PST - ppublish
SO  - Br J Haematol. 1995 Jul;90(3):693-6. doi: 10.1111/j.1365-2141.1995.tb05602.x.