PMID- 7647012
OWN - NLM
STAT- MEDLINE
DCOM- 19950925
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 90
IP  - 3
DP  - 1995 Jul
TI  - Trisomy 8 in acute promyelocytic leukaemia: an interphase study by fluorescence 
      in situ hybridization.
PG  - 697-700
AB  - Acute promyelocytic leukaemia (APL) is characterized by t(15;17)(q24;q21). 
      Trisomy 8 is the commonest accompanying karyotypic aberration. We investigated 14 
      APL patients for trisomy 8 using fluorescence in situ hybridization (FISH). 
      Conventional cytogenetic analysis showed trisomy 8 in two of nine successfully 
      karyotyped cases. With FISH, a possible third case showing a subclone (1-2.5%) 
      with trisomy 8 was found. The trisomy 8 clone size defined by karyotyping and 
      FISH was concordant in one case and discordant in another, in which trisomy 8 was 
      found in 100% of metaphases but only in 48% of leukaemic promyelocytes by FISH. 
      Therefore trisomy 8 was mosaic in all the cases, suggesting that it had arisen 
      from clonal evolution. All-trans-retinoic acid successfully induced morphologic 
      remission in both cases with trisomy 8.
FAU - Kwong, Y L
AU  - Kwong YL
AD  - University Department of Medicine, Queen Mary Hospital, Hong Kong.
FAU - Wong, K F
AU  - Wong KF
FAU - Chan, T K
AU  - Chan TK
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Adult
MH  - Aged
MH  - Child, Preschool
MH  - *Chromosomes, Human, Pair 8
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Interphase
MH  - Leukemia, Promyelocytic, Acute/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Trisomy
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
AID - 10.1111/j.1365-2141.1995.tb05603.x [doi]
PST - ppublish
SO  - Br J Haematol. 1995 Jul;90(3):697-700. doi: 10.1111/j.1365-2141.1995.tb05603.x.