PMID- 7649581
OWN - NLM
STAT- MEDLINE
DCOM- 19950928
LR  - 20220309
IS  - 0194-911X (Print)
IS  - 0194-911X (Linking)
VI  - 26
IP  - 3
DP  - 1995 Sep
TI  - Blood pressure in genetically hypertensive rats. Influence of the Y chromosome.
PG  - 452-9
AB  - We used a cross between the stroke-prone spontaneously hypertensive rat (SHRSP) 
      strain and the Wistar-Kyoto (WKY) normotensive strain to elucidate the genetic 
      basis of hypertension. Previous studies have reported conflicting evidence for 
      the contribution of the Y chromosome to hypertension in these models. To 
      investigate further the role of the Y chromosome in hypertension, we performed 
      two large reciprocal crosses: one with the SHRSP as a male progenitor of the 
      cross, yielding 60 F2 rats, and another with the WKY as a male progenitor, 
      yielding 83 F2 rats. The resulting F2 hybrids were phenotyped with the use of a 
      radiotelemetry system (Data Sciences) for measurement of systolic, diastolic, and 
      mean arterial pressures as well as heart rate and motor activity continuously for 
      96 hours at baseline and after 1% NaCl was added to the rats' drinking water for 
      12 days. Male F2 hybrids with the SHRSP grandfather had significantly higher 
      average systolic, diastolic, and mean arterial pressures at baseline compared 
      with male F2 hybrids with the WKY grandfather (188.7 +/- 18.1 versus 168.9 +/- 
      11.5, 130.3 +/- 14 versus 115.7 +/- 7.3, and 159.1 +/- 15.8 versus 141.5 +/- 9.4 
      mm Hg, respectively). These differences were also observed after salt loading 
      (197.9 +/- 22.1 versus 176.8 +/- 11.7, 136.5 +/- 17.3 versus 120.7 +/- 7.6, and 
      166.7 +/- 19.5 versus 148 +/- 9.7 mm Hg, respectively; P < .0001 for each 
      comparison). These results suggest that the SHRSP Y chromosome contains a locus 
      or loci that contribute to hypertension in SHRSP/WKY F2 hybrids.
FAU - Davidson, A O
AU  - Davidson AO
AD  - Department of Medicine and Therapeutics, University of Glasgow, Scotland.
FAU - Schork, N
AU  - Schork N
FAU - Jaques, B C
AU  - Jaques BC
FAU - Kelman, A W
AU  - Kelman AW
FAU - Sutcliffe, R G
AU  - Sutcliffe RG
FAU - Reid, J L
AU  - Reid JL
FAU - Dominiczak, A F
AU  - Dominiczak AF
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
SB  - IM
MH  - Animals
MH  - Blood Pressure
MH  - Chromosome Mapping
MH  - Female
MH  - Heart Rate
MH  - Hypertension/*genetics
MH  - Male
MH  - Motor Activity
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - *Y Chromosome
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 10.1161/01.hyp.26.3.452 [doi]
PST - ppublish
SO  - Hypertension. 1995 Sep;26(3):452-9. doi: 10.1161/01.hyp.26.3.452.