PMID- 7649790
OWN - NLM
STAT- MEDLINE
DCOM- 19950927
LR  - 20181113
IS  - 0021-8782 (Print)
IS  - 1469-7580 (Electronic)
IS  - 0021-8782 (Linking)
VI  - 185 ( Pt 3)
IP  - Pt 3
DP  - 1994 Dec
TI  - Hepatocyte growth factor (HGF/SF) is expressed in human epithelial cells during 
      embryonic development; studies by in situ hybridisation and northern blot 
      analysis.
PG  - 543-51
AB  - This study reports the tissue distribution of Hepatocyte Growth Factor-Scatter 
      Factor (HGF/SF) in human fetal tissue using Northern analysis and in situ 
      hybridisation techniques. In tissue from fetuses of 9-17 wk gestational age, the 
      6 kb mRNA transcript for HGF/SF was demonstrated in many tissues but prominently 
      in liver, intestine, gall bladder and spleen. In situ hybridisation demonstrated 
      that HGF/SF expression was not confined to mesenchymal tissues, as suggested by 
      previous studies but was expressed in epithelial tissues, particularly in small 
      intestine, keratinising epithelium of tongue, skin and oesophagus. In the small 
      intestine epithelial expression was strikingly regional, being confined to the 
      crypt region, the site of enterocyte proliferation. Northern analysis of tissues 
      for c-met mRNA, representing expression of the HGF/SF receptor, demonstrated 
      receptor expression in all tissues studied except the thyroid gland.
FAU - Wang, Y
AU  - Wang Y
AD  - Department of Medicine, Royal Postgraduate Medical School, London, UK.
FAU - Selden, C
AU  - Selden C
FAU - Farnaud, S
AU  - Farnaud S
FAU - Calnan, D
AU  - Calnan D
FAU - Hodgson, H J
AU  - Hodgson HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Anat
JT  - Journal of anatomy
JID - 0137162
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - *Blotting, Northern
MH  - Embryonic and Fetal Development/*physiology
MH  - Epithelium/chemistry/embryology/metabolism
MH  - Esophagus/chemistry/embryology
MH  - Gallbladder/chemistry/embryology
MH  - Hepatocyte Growth Factor/analysis/*metabolism
MH  - Humans
MH  - *In Situ Hybridization
MH  - Intestines/chemistry/embryology
MH  - Liver/chemistry/embryology
MH  - Mesoderm/chemistry/*metabolism
MH  - Proto-Oncogene Proteins c-met
MH  - Receptor Protein-Tyrosine Kinases/metabolism
MH  - Skin/chemistry/embryology
MH  - Spleen/chemistry/embryology
MH  - Tongue/chemistry/embryology
PMC - PMC1166661
EDAT- 1994/12/01 00:00
MHDA- 1994/12/01 00:01
PMCR- 1996/12/01
CRDT- 1994/12/01 00:00
PHST- 1994/12/01 00:00 [pubmed]
PHST- 1994/12/01 00:01 [medline]
PHST- 1994/12/01 00:00 [entrez]
PHST- 1996/12/01 00:00 [pmc-release]
PST - ppublish
SO  - J Anat. 1994 Dec;185 ( Pt 3)(Pt 3):543-51.