PMID- 7652576
OWN - NLM
STAT- MEDLINE
DCOM- 19950926
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 269
IP  - 5228
DP  - 1995 Sep 1
TI  - Commitment of CNS progenitors along the dorsoventral axis of Drosophila 
      neuroectoderm.
PG  - 1278-81
AB  - In the Drosophila embryo, the central nervous system (CNS) develops from a 
      population of neural stem cells (neuroblasts) and midline progenitor cells. Here, 
      the fate and extent of determination of CNS progenitors along the dorsoventral 
      axis was assayed. Dorsal neuroectodermal cells transplanted into the ventral 
      neuroectoderm or into the midline produced CNS lineages consistent with their new 
      position. However, ventral neuroectodermal cells and midline cells transplanted 
      to dorsal sites of the neuroectoderm migrated ventrally and produced CNS lineages 
      consistent with their origin. Thus, inductive signals at the ventral midline and 
      adjacent neuroectoderm may confer ventral identities to CNS progenitors as well 
      as the ability to assume and maintain characteristic positions in the developing 
      CNS. Furthermore, ectopic transplantations of wild-type midline cells into single 
      minded (sim) mutant embryos suggest that the ventral midline is required for 
      correct positioning of the cells.
FAU - Udolph, G
AU  - Udolph G
AD  - Institut fur Genetik, Universitat Mainz, Germany.
FAU - Luer, K
AU  - Luer K
FAU - Bossing, T
AU  - Bossing T
FAU - Technau, G M
AU  - Technau GM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
SB  - IM
MH  - Animals
MH  - Cell Movement
MH  - Cell Transplantation
MH  - Central Nervous System/embryology
MH  - Drosophila/*embryology
MH  - Ectoderm/cytology/*physiology
MH  - Gastrula/cytology
MH  - Mutation
MH  - Neuroglia/cytology
MH  - Neurons/*cytology
MH  - Stem Cell Transplantation
MH  - Stem Cells/*cytology/physiology
MH  - Transplantation, Heterotopic
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 10.1126/science.7652576 [doi]
PST - ppublish
SO  - Science. 1995 Sep 1;269(5228):1278-81. doi: 10.1126/science.7652576.