PMID- 7653602
OWN - NLM
STAT- MEDLINE
DCOM- 19950922
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 269
IP  - 2 Pt 2
DP  - 1995 Aug
TI  - NaCl injections in brain induce natriuresis and blood pressure responses 
      sensitive to ANG II AT1 receptors.
PG  - F282-8
AB  - In the present study we tested the hypothesis that the natriuretic and pressor 
      effects of intracerebroventricularly (icv) injected hypertonic saline involve a 
      central angiotensinergic pathway. All experiments were performed in conscious 
      Wistar rats. Bolus injections of hypertonic saline (0.19, 0.23, 0.30, and 0.60 M 
      icv; injection volume 5 microliters) induced a concentration-dependent increase 
      of renal sodium excretion without affecting urinary flow. The increase in renal 
      sodium excretion after the two highest saline concentrations was accompanied by 
      significant increases in mean arterial blood pressure (MAP). Pretreatment with 
      the angiotensin (ANG) AT1 receptor antagonist, losartan (5 micrograms icv), 
      reduced the natriuretic effect of 0.23 and 0.30 M saline but did not affect the 
      natriuresis induced by 0.60 M saline. The increase in MAP after 0.30 and 0.60 M 
      saline icv was markedly attenuated by intracerebroventricular pretreatment with 
      losartan. Our results demonstrate the involvement of a central angiotensinergic 
      mechanism in the natriuretic and pressor responses to hypertonic saline. In 
      addition to the ANG II-mediated natriuresis, an additional natriuretic mechanism, 
      independent of ANG II and associated with the saline-induced pressor effect, 
      seems to be recruited with increasing concentrations of saline in the 
      cerebrospinal fluid.
FAU - Rohmeiss, P
AU  - Rohmeiss P
AD  - Department of Pharmacology, University of Kiel, Germany.
FAU - Beyer, C
AU  - Beyer C
FAU - Nagy, E
AU  - Nagy E
FAU - Tschope, C
AU  - Tschope C
FAU - Hohle, S
AU  - Hohle S
FAU - Strauch, M
AU  - Strauch M
FAU - Unger, T
AU  - Unger T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Angiotensin Receptor Antagonists)
RN  - 0 (Biphenyl Compounds)
RN  - 0 (Imidazoles)
RN  - 0 (Pyridines)
RN  - 0 (Receptors, Angiotensin)
RN  - 0 (Saline Solution, Hypertonic)
RN  - 0 (Tetrazoles)
RN  - 11128-99-7 (Angiotensin II)
RN  - 114785-12-5 (PD 123177)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - JMS50MPO89 (Losartan)
SB  - IM
MH  - Angiotensin II/antagonists & inhibitors
MH  - Angiotensin Receptor Antagonists
MH  - Animals
MH  - Biphenyl Compounds/pharmacology
MH  - Blood Pressure/*drug effects
MH  - Brain/*physiology
MH  - Imidazoles/pharmacology
MH  - Injections
MH  - Losartan
MH  - Male
MH  - Natriuresis/*drug effects
MH  - Pyridines/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Angiotensin/*physiology
MH  - Saline Solution, Hypertonic/pharmacology
MH  - Sodium Chloride/*pharmacology
MH  - Tetrazoles/pharmacology
EDAT- 1995/08/01 00:00
MHDA- 1995/08/01 00:01
CRDT- 1995/08/01 00:00
PHST- 1995/08/01 00:00 [pubmed]
PHST- 1995/08/01 00:01 [medline]
PHST- 1995/08/01 00:00 [entrez]
AID - 10.1152/ajprenal.1995.269.2.F282 [doi]
PST - ppublish
SO  - Am J Physiol. 1995 Aug;269(2 Pt 2):F282-8. doi: 10.1152/ajprenal.1995.269.2.F282.