PMID- 7656580
OWN - NLM
STAT- MEDLINE
DCOM- 19951004
LR  - 20180214
IS  - 0301-0171 (Print)
IS  - 0301-0171 (Linking)
VI  - 71
IP  - 2
DP  - 1995
TI  - Meiotic segregation of the X and Y chromosomes and chromosome 1 analyzed by 
      three-color FISH in human interphase spermatozoa.
PG  - 126-30
AB  - Meiotic segregation of the X and Y chromosomes and chromosome 1 was analyzed by 
      three-color fluorescence in situ hybridization (FISH) in 94,575 human interphase 
      spermatozoa from four control subjects. More than 99% of the sperm cells were 
      labeled. The proportions of X- and Y-bearing sperm were estimated to be 49.83% 
      and 48.30%, respectively. The disomy rates were 0.04%, 0.009%, and 0.20% for the 
      X and Y chromosomes and chromosome 1, respectively. Hyperhaploidy with an extra 
      gonosome was found in 0.34% of spermatozoa, due to nondisjunction during meiosis 
      I. The frequency of diploidy was 0.11% at meiosis I and 0.036% at meiosis II. 
      Cohybridization of one autosomal and two gonosomal probes, in three-color FISH in 
      interphase spermatozoa, seems to accurately discriminate diploidies from 
      disomies, as well as the meiotic origin of gonosomal aneuploidies in sperm cells.
FAU - Chevret, E
AU  - Chevret E
AD  - Reproductive Biology Unit, Albert Bonniot Institute, Grenoble University Medical 
      School, La Tronche, France.
FAU - Rousseaux, S
AU  - Rousseaux S
FAU - Monteil, M
AU  - Monteil M
FAU - Pelletier, R
AU  - Pelletier R
FAU - Cozzi, J
AU  - Cozzi J
FAU - Sele, B
AU  - Sele B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Cytogenet Cell Genet
JT  - Cytogenetics and cell genetics
JID - 0367735
RN  - 0 (DNA Probes)
SB  - IM
MH  - DNA Probes
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Interphase
MH  - Male
MH  - Meiosis/*genetics
MH  - Sex Chromosomes/*genetics
MH  - Spermatozoa/*chemistry/ultrastructure
MH  - X Chromosome
MH  - Y Chromosome
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1159/000134090 [doi]
PST - ppublish
SO  - Cytogenet Cell Genet. 1995;71(2):126-30. doi: 10.1159/000134090.