PMID- 7657024
OWN - NLM
STAT- MEDLINE
DCOM- 19951004
LR  - 20190515
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 44
IP  - 9
DP  - 1995 Sep
TI  - Immunogenetic determinants and prediction of IDDM in French schoolchildren.
PG  - 1029-32
AB  - Islet cell antibodies (ICAs) are predictive markers of the disease in 
      first-degree relatives of patients with insulin-dependent diabetes mellitus 
      (IDDM). The large majority of newly diagnosed cases, however, will develop in 
      children with no family history of diabetes. In France, the risk for development 
      of IDDM up to the age of 20 years is 60 times higher in first-degree relatives 
      than in the general population. The aim of this study was to test whether data 
      collected in the first-degree relatives of IDDM patients could be transferred to 
      children for the prediction of overt diabetes. A large population-based cohort of 
      French school-aged children (n = 13,380; ages 6-17 years) were screened for ICAs, 
      and results were compared with those of 1,185 first-degree relatives of IDDM 
      patients. ICA prevalence rates were significantly different in the two 
      populations (5.5% vs. 1.5%; P < 0.0001), with a significantly higher proportion 
      of high ICA titers in first-degree relatives (37%) than in schoolchildren (14%) 
      (P = 0.0005). ICA titers remained remarkably stable in children over 4 years. 
      Insulin autoantibodies (IAAs) were found in 3.4 and 15.4% of ICA+ children and 
      first-degree relatives, respectively. Susceptibility alleles at the human 
      leukocyte antigen (HLA)-DQB1 locus were observed significantly more frequently in 
      children in whom ICA titers > or = 20 Juvenile Diabetes Foundation units (JDF U) 
      were found on two separate occasions (67%) than in ICA- children (52%) (P = 
      0.05). Five subjects developed overt diabetes during follow-up. ICA titers of > 
      20 JDF U were found in all of them on the first sample and at follow-up.(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Levy-Marchal, C
AU  - Levy-Marchal C
AD  - INSERM, CJF 93-13, Hopital Robert Debre, Paris, France.
FAU - Dubois, F
AU  - Dubois F
FAU - Noel, M
AU  - Noel M
FAU - Tichet, J
AU  - Tichet J
FAU - Czernichow, P
AU  - Czernichow P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQbeta antigen)
RN  - 0 (islet cell antibody)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Alleles
MH  - Autoantibodies/*blood
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/epidemiology/*genetics/*immunology
MH  - Family
MH  - Female
MH  - France
MH  - HLA-DQ Antigens/blood/*genetics
MH  - HLA-DQ beta-Chains
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immunogenetics/methods
MH  - Islets of Langerhans/immunology
MH  - Male
MH  - Middle Aged
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 10.2337/diab.44.9.1029 [doi]
PST - ppublish
SO  - Diabetes. 1995 Sep;44(9):1029-32. doi: 10.2337/diab.44.9.1029.