PMID- 7657349
OWN - NLM
STAT- MEDLINE
DCOM- 19951005
LR  - 20161020
IS  - 0257-7712 (Print)
IS  - 0257-7712 (Linking)
VI  - 26
IP  - 1
DP  - 1995 Mar
TI  - [Clinical value of measurement of serum creatine kinase BB and neuron specific 
      enolase for small cell lung cancer].
PG  - 90-3
AB  - Serum creatine kinase BB (CK-BB) and neuron specific enolase (NSE) were measured 
      with chromatography-fluorometric method and ABC-ELISA in 20 patients with small 
      cell lung cancer (SCLC), 30 patients with non small cell lung cancer (NSCLC), 25 
      patients with benign pulmonary diseases (BPD) and 30 healthy subjects (C). The 
      results revealed that serum concentrations of CK-BB and NSE in SCLC were 
      significantly greater than those in other three groups (P < 0.001). The mean 
      values of CK-BB and NSE in SCLC, NSCLC, BPD, C were 30.2, 8.4, 6.3, 4.3 IU/L and 
      52.2, 12.7, 10.3, 9.2 ng/ml, respectively. If values above 9.5 IU/L (CK-BB) and 
      20.8 ng/ml (NSE) were considered abnormal, 70% and 80% of the values of CK-BB and 
      NSE in SCLC were positive, respectively, which were higher than those in NSCLC (P 
      < 0.005). The serum levels of CK-BB had linear correlation with those of NSE in 
      SCLC (r = 0.7934, P < 0.001). By combined determination, the sensitivity and 
      specificity were increased to 90% and 94% respectively. Therefore, the results 
      suggest that serum CK-BB and NSE be diagnostic markers for SCLC. Concurrent 
      determination may raise their value in clinical use.
FAU - Zhou, J
AU  - Zhou J
AD  - Department of Pathophysiology, Cancer Research Institute of Guizhou Province.
FAU - Xiong, Q
AU  - Xiong Q
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Hua Xi Yi Ke Da Xue Xue Bao
JT  - Hua xi yi ke da xue xue bao = Journal of West China University of Medical 
      Sciences = Huaxi yike daxue xuebao
JID - 8609552
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Isoenzymes)
RN  - EC 2.7.3.2 (Creatine Kinase)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*blood
MH  - Carcinoma, Small Cell/diagnosis/*enzymology
MH  - Creatine Kinase/*blood
MH  - Female
MH  - Humans
MH  - Isoenzymes
MH  - Lung Neoplasms/diagnosis/*enzymology
MH  - Male
MH  - Middle Aged
MH  - Phosphopyruvate Hydratase/*blood
EDAT- 1995/03/01 00:00
MHDA- 1995/03/01 00:01
CRDT- 1995/03/01 00:00
PHST- 1995/03/01 00:00 [pubmed]
PHST- 1995/03/01 00:01 [medline]
PHST- 1995/03/01 00:00 [entrez]
PST - ppublish
SO  - Hua Xi Yi Ke Da Xue Xue Bao. 1995 Mar;26(1):90-3.