PMID- 7657524
OWN - NLM
STAT- MEDLINE
DCOM- 19951003
LR  - 20071114
IS  - 0251-1789 (Print)
IS  - 0251-1789 (Linking)
VI  - 14
IP  - 1-6
DP  - 1994-1995
TI  - Mechanisms of transforming growth factor-beta 1-induced cell cycle arrest.
PG  - 309-18
AB  - Mitogenic stimulation of normal cells initiates a sequence of events leading to 
      activation of cyclin-dependent kinases, phosphorylation of Rb, and subsequent 
      entry of the cell into the S phase. Evidence is accumulating that transforming 
      growth factor-beta 1 (TGF beta 1) inhibits cell cycle progression by blocking a 
      number of steps involved in cdk activation, thus preventing the massive 
      phosphorylation of Rb in late G1. Many types of cancer have lost sensitivity to 
      the growth-inhibitory actions of TGF beta 1, which is thought to be an important 
      step in the process of oncogenic transformation. Recent findings suggest that in 
      many cancers TGF beta 1 insensitivity may result from disregulated expression of 
      cyclin, cdk, and cdk inhibitor genes. These alterations allow inappropriate cdk 
      activation and Rb phosphorylation, resulting in inactivation of the growth 
      suppressive functions of Rb and uninhibited S phase entry. Further work will be 
      needed to clarify the mechanisms of cdk inhibition by TGF beta 1 and how these 
      events are linked to TGF beta 1 receptor-ligand binding and signaling.
FAU - Satterwhite, D J
AU  - Satterwhite DJ
AD  - Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, 
      Tenn. 37232-2175, USA.
FAU - Moses, H L
AU  - Moses HL
LA  - eng
GR  - CA42572/CA/NCI NIH HHS/United States
GR  - CA48799/CA/NCI NIH HHS/United States
GR  - HD-00850./HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Switzerland
TA  - Invasion Metastasis
JT  - Invasion & metastasis
JID - 8202435
RN  - 0 (Cyclins)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
GS  - MTS1
GS  - Rb
GS  - c-myc
MH  - Animals
MH  - Cell Cycle/physiology
MH  - Cell Transformation, Neoplastic/genetics/*pathology
MH  - Cyclins/genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Neoplasms/genetics/*pathology
MH  - Transforming Growth Factor beta/*physiology
RF  - 69
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PST - ppublish
SO  - Invasion Metastasis. 1994-1995;14(1-6):309-18.