PMID- 7657528
OWN - NLM
STAT- MEDLINE
DCOM- 19951003
LR  - 20061115
IS  - 0251-1789 (Print)
IS  - 0251-1789 (Linking)
VI  - 14
IP  - 1-6
DP  - 1994-1995
TI  - Murine models of liver metastasis.
PG  - 349-61
AB  - Even though the liver is a relevant metastatic site for several human malignant 
      tumors, mechanisms or organ-specific metastasis to the liver remain largely 
      unknown. In the following paper we summarize the results obtained with different 
      murine model systems which have been set up to elucidate the above mechanisms, 
      and describe our own results with two murine models: the F9 teratocarcinoma and 
      the B16 melanoma. While the F9 teratocarcinoma model system underscores the roles 
      of both adhesion and growth stimulation in the target organ, the B16 melanoma 
      model strengthens the relevance of paracrine growth stimulation. Moreover, B16 
      melanoma cells selected in vivo for increased liver colonization ability appear 
      to depend on cell-to-cell contact with hepatocytes in order to gain efficient 
      growth stimulation. When we next tried to identify the molecule(s) responsible 
      for the growth effect in a liver plasma membrane extract, we found that such 
      activity was mediated by two closely related protein bands. These turned out to 
      be two different forms of transferrin (Tf), one of which is specifically present 
      on the hepatocyte surface. Moreover, when we analyzed the different B16 lines for 
      the expression of c-Met[the receptor for the hepatocyte growth factor-scatter 
      factor (HGF/SF)], we found that liver-specific LS9 had more of this protein than 
      lung-specific F10 or parental F1, suggesting a role for HGF/SF in liver 
      colonization by B16 melanoma cells.
FAU - Rusciano, D
AU  - Rusciano D
AD  - Friedrich Miescher Institut, Basel, Switzerland.
FAU - Lorenzoni, P
AU  - Lorenzoni P
FAU - Burger, M
AU  - Burger M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Invasion Metastasis
JT  - Invasion & metastasis
JID - 8202435
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Disease Models, Animal
MH  - Liver Neoplasms, Experimental/*secondary
MH  - Melanoma, Experimental/*pathology/*secondary
MH  - Mice
MH  - Molecular Sequence Data
MH  - Teratocarcinoma/*pathology/*secondary
RF  - 56
EDAT- 1994/01/01 00:00
MHDA- 1994/01/01 00:01
CRDT- 1994/01/01 00:00
PHST- 1994/01/01 00:00 [pubmed]
PHST- 1994/01/01 00:01 [medline]
PHST- 1994/01/01 00:00 [entrez]
PST - ppublish
SO  - Invasion Metastasis. 1994-1995;14(1-6):349-61.