PMID- 7657849
OWN - NLM
STAT- MEDLINE
DCOM- 19950929
LR  - 20190825
IS  - 0091-2700 (Print)
IS  - 0091-2700 (Linking)
VI  - 35
IP  - 5
DP  - 1995 May
TI  - Comparison of the pharmacokinetics of two nicotine transdermal systems: nicoderm 
      and habitrol.
PG  - 493-8
AB  - This randomized, crossover study compared the nicotine and cotinine 
      pharmacokinetic parameters and plasma concentration profiles of two different 
      nicotine transdermal products: Nicoderm (Alza, Palo Alto, CA; and Marion Merrell 
      Dow, Kansas City, MO) and Habitrol (Basel Pharmaceuticals, Summit, NJ). The two 
      treatments were randomly assigned to each of 24 male smokers and worn for 24 
      hours each day for 5 days, with a 6-day washout between treatments. Plasma 
      nicotine and cotinine concentrations were measured on day 1 and day 5 of each 
      treatment. Mean delivered dose differed significantly between products, and the 
      two products were not bioequivalent. The Nicoderm system provided higher mean 
      plasma nicotine concentrations, particularly during the first 8 hours after 
      system application. The mean steady state Cmax, AUC, and degree of fluctuation 
      (DF) values were significantly greater for the Nicoderm system than for Habitrol. 
      The mean nicotine tmax value for the Nicoderm system was significantly shorter (P 
      < .001) than that for Habitrol (2.7 versus 8.6 hours). Steady state cotinine AUC 
      values and plasma concentrations were significantly lower for Habitrol than for 
      the Nicoderm system. The incidence of adverse events was similar for both 
      products.
FAU - Gupta, S K
AU  - Gupta SK
AD  - Alza Corporation, Palo Alto, California 94304, USA.
FAU - Okerholm, R A
AU  - Okerholm RA
FAU - Eller, M
AU  - Eller M
FAU - Wei, G
AU  - Wei G
FAU - Rolf, C N
AU  - Rolf CN
FAU - Gorsline, J
AU  - Gorsline J
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - J Clin Pharmacol
JT  - Journal of clinical pharmacology
JID - 0366372
RN  - 6M3C89ZY6R (Nicotine)
RN  - K5161X06LL (Cotinine)
SB  - IM
MH  - Administration, Cutaneous
MH  - Adult
MH  - Analysis of Variance
MH  - Cotinine/blood/*pharmacokinetics
MH  - Cross-Over Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nicotine/blood/*pharmacokinetics
EDAT- 1995/05/01 00:00
MHDA- 1995/05/01 00:01
CRDT- 1995/05/01 00:00
PHST- 1995/05/01 00:00 [pubmed]
PHST- 1995/05/01 00:01 [medline]
PHST- 1995/05/01 00:00 [entrez]
AID - 10.1002/j.1552-4604.1995.tb04093.x [doi]
PST - ppublish
SO  - J Clin Pharmacol. 1995 May;35(5):493-8. doi: 10.1002/j.1552-4604.1995.tb04093.x.