PMID- 7659189
OWN - NLM
STAT- MEDLINE
DCOM- 19951004
LR  - 20180214
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 61
IP  - 6
DP  - 1995 Jun
TI  - The antiglucocorticoid, RU486, attenuates stress-induced decreases in 
      plasma-luteinizing hormone concentrations in male rats.
PG  - 638-45
AB  - The present studies investigated the role of glucocorticoid receptors (GR) in the 
      inhibitory effects of acute and chronic immobilization stress on pituitary 
      luteinizing hormone (LH) release. Systemic administration of the GR antagonist, 
      RU486, significantly attenuated the acute decline in circulating LH observed in 
      intact male rats immobilized by encasement within paper cocoons. Whereas 
      vehicle-injected controls exhibited a significant reduction in plasma LH between 
      +1 and +5 h of stress, animals given subcutaneous (sc) injections of 2.5 mg 
      RU846/kg did not exhibit a reduction in circulating LH until 4 h after initiation 
      of stress. Plasma LH levels in the GR-treated group were significantly elevated 
      compared to the vehicle controls between +1 and +3 h of stress. Repetitive 
      exposure to the same stress stimulus 24 and 48 h later resulted in decreased 
      plasma LH levels in the vehicle-treated rats, but not in the animals injected sc 
      with RU486. Other studies showed that intracerebroventricular (icv) 
      administration of RU486 (10.0 micrograms/rat) also blunted the inhibitory effects 
      of acute and chronic immobilization stress on pituitary LH release. In 
      experiments designed to evaluate whether activation of central GR can influence 
      the magnitude and/or temporal characteristics of the LH secretory response to 
      acute inhibitory stress, it was observed that animals pretreated by icv injection 
      of the GR agonist, RU362, exhibited a greater reduction in plasma LH levels 
      during the first hour of stress, as compared to rats pretreated with vehicle 
      alone. In summary, the present findings that pharmacologic antagonism of GR 
      attenuates acute and chronic stress-induced inhibition of circulating LH support 
      a role for glucocorticoids in mechanisms underlying suppression of pituitary LH 
      release during stress.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Briski, K P
AU  - Briski KP
AD  - Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, 
      College of Veterinary Medicine, Washington State University, Pullman 99164-6520, 
      USA.
FAU - Vogel, K L
AU  - Vogel KL
FAU - McIntyre, A R
AU  - McIntyre AR
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 320T6RNW1F (Mifepristone)
RN  - 9002-67-9 (Luteinizing Hormone)
SB  - IM
MH  - Animals
MH  - Immobilization
MH  - Injections, Intraventricular
MH  - Injections, Subcutaneous
MH  - Luteinizing Hormone/*blood
MH  - Male
MH  - Mifepristone/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stress, Psychological/*blood
EDAT- 1995/06/01 00:00
MHDA- 1995/06/01 00:01
CRDT- 1995/06/01 00:00
PHST- 1995/06/01 00:00 [pubmed]
PHST- 1995/06/01 00:01 [medline]
PHST- 1995/06/01 00:00 [entrez]
AID - 10.1159/000126890 [doi]
PST - ppublish
SO  - Neuroendocrinology. 1995 Jun;61(6):638-45. doi: 10.1159/000126890.