PMID- 7659880
OWN - NLM
STAT- MEDLINE
DCOM- 19951004
LR  - 20131121
IS  - 0034-9887 (Print)
IS  - 0034-9887 (Linking)
VI  - 122
IP  - 10
DP  - 1994 Oct
TI  - [Digoxin is effective in th treatment of patients with heart failure and sinus 
      rhythm].
PG  - 1147-52
AB  - Due to differences in treatment effect in studies on the effectiveness of digoxin 
      in patients with congestive heart failure in sinus rhythm, a cross-over 
      placebo-controlled, randomized double blind clinical trial was performed. Thirty 
      one patients, without previous treatment with digoxin, in New York Heart 
      Association (NYHA) functional class II to IV, with a dilated left ventricle 
      and/or ventricular systolic dysfunction were included. Patients received digoxin, 
      adjusted for blood levels, or placebo, during an 8 week period, prior to crossing 
      over to the other treatment for another 8 weeks. The order of treatments was 
      randomly allocated. Outcome measurement were performed at the end of each 8 week 
      period. Digoxin, compared with placebo, improved NYHA class, 6.9% vs 41.4% (p = 
      0.013) and increased the treadmill exercise time, 406 +/- 204 s vs 484 +/- 185 s 
      (p = 0.003). During the digoxin treatment the left ventricular and systolic 
      diameter was reduced from 52.9 +/- 8.9 to 50.1 +/- 9.7 mm (p = 0.016) and the 
      shortening fraction increased from 21.4 +/- 8.3 to 24.8 +/- 8.1% (p = 0.009). No 
      significant difference was observed in the left ventricular end diastolic 
      diameter (LVED) of the left ventricle and in a estimation of quality of life. In 
      conclusion, digoxin treatment produced a significant improvement in functional 
      capacity, exercise time, and left ventricular performance.
FAU - Lanas, F
AU  - Lanas F
AD  - Unidad de Cardiologia, Factultad de Medicina, Universidad de La Frontera, Temuco, 
      Chile.
FAU - Standen, D
AU  - Standen D
FAU - Steinmann, W C
AU  - Steinmann WC
FAU - Montecinos, A
AU  - Montecinos A
FAU - Stockins, B
AU  - Stockins B
LA  - spa
PT  - Clinical Trial
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
TT  - La digoxina es efectiva en el tratamiento de pacientes con insuficiencia cardiaca 
      y ritmo sinusal.
PL  - Chile
TA  - Rev Med Chil
JT  - Revista medica de Chile
JID - 0404312
RN  - 73K4184T59 (Digoxin)
SB  - IM
MH  - Adult
MH  - Digoxin/*therapeutic use
MH  - Double-Blind Method
MH  - Exercise Test/methods
MH  - Female
MH  - Heart Failure/*drug therapy/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sinoatrial Node/*physiopathology
EDAT- 1994/10/01 00:00
MHDA- 1994/10/01 00:01
CRDT- 1994/10/01 00:00
PHST- 1994/10/01 00:00 [pubmed]
PHST- 1994/10/01 00:01 [medline]
PHST- 1994/10/01 00:00 [entrez]
PST - ppublish
SO  - Rev Med Chil. 1994 Oct;122(10):1147-52.