PMID- 7660336
OWN - NLM
STAT- MEDLINE
DCOM- 19950929
LR  - 20190503
IS  - 0040-6376 (Print)
IS  - 1468-3296 (Electronic)
IS  - 0040-6376 (Linking)
VI  - 50
IP  - 3
DP  - 1995 Mar
TI  - Static lung compliance in chronic heart failure: relation with dyspnoea and 
      exercise capacity.
PG  - 245-8
AB  - BACKGROUND: The pathogenesis of dyspnoea in patients with chronic heart failure 
      is poorly understood. Static lung compliance is reduced in chronic heart failure. 
      The relation between static lung compliance and exercise capacity and dyspnoea in 
      chronic heart failure has been investigated. METHODS: Static lung compliance was 
      calculated from expiratory pressure-volume curves in 18 patients with chronic 
      heart failure (three women, mean age 62 years). Catheter mounted pressure 
      transducers were used to measure changes in oesophageal pressure. Changes in lung 
      volume were determined by integrating flow at the mouth, measured by a 
      pneumotachograph. New York Heart Association (NYHA) class for dyspnoea was 
      determined by a single observer. Patients underwent treadmill exercise to symptom 
      limited maximum using staged and fixed rate protocols. Borg ratings for dyspnoea 
      at submaximal exercise were measured. RESULTS: Static lung compliance, whether 
      expressed as % total lung capacity (TLC)/cm H2O or % predicted TLC/cm H2O, was 
      unrelated to NYHA class. Similarly, there was no relation between static lung 
      compliance and exercise capacity with either protocol or with Borg ratings for 
      dyspnoea at submaximal exercise, with the exception of that measured after 11 
      minutes of the staged protocol. CONCLUSIONS: Static lung compliance at rest has 
      no relation with treadmill exercise capacity in chronic heart failure, and its 
      relation with measures of dyspnoea is variable. No role for lung elasticity in 
      determining the symptomatology of chronic heart failure was found.
FAU - Evans, S A
AU  - Evans SA
AD  - University Hospital, Nottingham, UK.
FAU - Watson, L
AU  - Watson L
FAU - Cowley, A J
AU  - Cowley AJ
FAU - Johnston, I D
AU  - Johnston ID
FAU - Kinnear, W J
AU  - Kinnear WJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Thorax
JT  - Thorax
JID - 0417353
SB  - IM
MH  - Cardiac Output/physiology
MH  - Cardiac Volume/physiology
MH  - Dyspnea/*etiology/physiopathology
MH  - Exercise Test
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Heart Failure/complications/*physiopathology
MH  - Humans
MH  - Lung Compliance/*physiology
MH  - Lung Volume Measurements
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Ventilation/physiology
MH  - Pulmonary Wedge Pressure/physiology
PMC - PMC1021186
EDAT- 1995/03/01 00:00
MHDA- 1995/03/01 00:01
PMCR- 1998/03/01
CRDT- 1995/03/01 00:00
PHST- 1995/03/01 00:00 [pubmed]
PHST- 1995/03/01 00:01 [medline]
PHST- 1995/03/01 00:00 [entrez]
PHST- 1998/03/01 00:00 [pmc-release]
AID - 10.1136/thx.50.3.245 [doi]
PST - ppublish
SO  - Thorax. 1995 Mar;50(3):245-8. doi: 10.1136/thx.50.3.245.