PMID- 7662615
OWN - NLM
STAT- MEDLINE
DCOM- 19951012
LR  - 20190920
IS  - 0920-5063 (Print)
IS  - 0920-5063 (Linking)
VI  - 7
IP  - 1
DP  - 1995
TI  - Fabrication of biodegradable polymer scaffolds to engineer trabecular bone.
PG  - 23-38
AB  - We present a novel method for manufacturing three-dimensional, biodegradable 
      poly(DL-lactic-co-glycolic acid) (PLGA) foam scaffolds for use in bone 
      regeneration. The technique involves the formation of a composite material 
      consisting of gelatin microspheres surrounded by a PLGA matrix. The gelatin 
      microspheres are leached out leaving an open-cell foam with a pore size and 
      morphology defined by the gelatin microspheres. The foam porosity can be 
      controlled by altering the volume fraction of gelatin used to make the composite 
      material. PLGA 50:50 was used as a model degradable polymer to establish the 
      effect of porosity, pore size, and degradation on foam mechanical properties. The 
      yield strengths and moduli in compression of PLGA 50:50 foams were found to 
      decrease with increasing porosity according to power law relationships. These 
      mechanical properties were however, largely unaffected by pore size. Foams with 
      yield strengths up to 3.2 MPa were manufactured. From in vitro degradation 
      studies we established that for PLGA 50:50 foams the mechanical properties 
      declined in parallel with the decrease in molecular weight. Below a weight 
      average molecular weight of 10,000 the foam had very little mechanical strength 
      (0.02 MPa). These results indicate that PLGA 50:50 foams are not suitable for 
      replacement of trabecular bone. However, the dependence of mechanical properties 
      on porosity, pore size, and degree of degradation which we have determined will 
      aid us in designing a biodegradable scaffold suitable for bone regeneration.
FAU - Thomson, R C
AU  - Thomson RC
AD  - Cox Laboratory for Biomedical Engineering, Department of Chemical Engineering, 
      Rice University, Houston, TX 77251-1892, USA.
FAU - Yaszemski, M J
AU  - Yaszemski MJ
FAU - Powers, J M
AU  - Powers JM
FAU - Mikos, A G
AU  - Mikos AG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - J Biomater Sci Polym Ed
JT  - Journal of biomaterials science. Polymer edition
JID - 9007393
RN  - 0 (Bone Substitutes)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 9000-70-8 (Gelatin)
SB  - IM
MH  - Analysis of Variance
MH  - Biomechanical Phenomena
MH  - Bone Regeneration/physiology
MH  - Bone Substitutes/chemistry/*standards
MH  - Chromatography, Gel
MH  - Feasibility Studies
MH  - Gelatin/chemistry
MH  - Humans
MH  - In Vitro Techniques
MH  - *Lactic Acid
MH  - Microscopy, Electron, Scanning
MH  - Microspheres
MH  - Molecular Weight
MH  - *Polyglycolic Acid
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/chemistry/*metabolism
MH  - Porosity
MH  - Prostheses and Implants/*standards
MH  - Prosthesis Design
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1163/156856295x00805 [doi]
PST - ppublish
SO  - J Biomater Sci Polym Ed. 1995;7(1):23-38. doi: 10.1163/156856295x00805.