PMID- 7664251
OWN - NLM
STAT- MEDLINE
DCOM- 19951011
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 82
IP  - 2
DP  - 1995 Jul 15
TI  - Application of FISH to complex chromosomal rearrangements associated with chronic 
      myelogenous leukemia.
PG  - 93-9
AB  - Identification of complex chromosomal rearrangements can be difficult, due either 
      to the limited number and sometimes poor quality of metaphases in bone marrow 
      preparations or to the nature of the rearrangements. Fluorescence in situ 
      hybridization (FISH) using chromosome-specific DNA libraries in conjunction with 
      a cosmid probe for the c-ABL oncogene was performed to substantiate the 
      preliminary G-banded karyotypes of six patients with chronic myelogenous leukemia 
      (CML). Our results indicate that FISH is sufficiently sensitive to detect complex 
      and subtle rearrangements, even in bone marrow preparations with suboptimal 
      metaphases, and can provide valuable corroborative information.
FAU - Sullivan, B A
AU  - Sullivan BA
AD  - Department of OB/GYN, University of Maryland, Baltimore, USA.
FAU - Schiffer, C A
AU  - Schiffer CA
FAU - Patil, S R
AU  - Patil SR
FAU - Hulseberg, D
AU  - Hulseberg D
FAU - Leana-Cox, J
AU  - Leana-Cox J
FAU - Schwartz, S
AU  - Schwartz S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA Probes)
SB  - IM
MH  - Bone Marrow/ultrastructure
MH  - *Chromosome Aberrations
MH  - DNA Probes
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics
MH  - Philadelphia Chromosome
EDAT- 1995/07/15 00:00
MHDA- 1995/07/15 00:01
CRDT- 1995/07/15 00:00
PHST- 1995/07/15 00:00 [pubmed]
PHST- 1995/07/15 00:01 [medline]
PHST- 1995/07/15 00:00 [entrez]
AID - 016546089400075M [pii]
AID - 10.1016/0165-4608(94)00075-m [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1995 Jul 15;82(2):93-9. doi: 
      10.1016/0165-4608(94)00075-m.