PMID- 7666039
OWN - NLM
STAT- MEDLINE
DCOM- 19951010
LR  - 20220310
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 45
IP  - 4
DP  - 1995 Apr
TI  - Human T-cell lymphotropic virus type I in Iranian-born Mashhadi Jews: genetic and 
      phylogenetic evidence for common source of infection.
PG  - 361-6
AB  - High prevalence of human T-cell lymphotropic virus type I (HTLV-I) infection and 
      disease has been identified among Iranian-born Mashhadi Jews, an ethnically 
      segregated, highly inbred population. To determine the origin and genetic 
      diversity of HTLV-I in this group, 1,039 bp spanning selected regions of the 
      HTLV-I gag, pol, env and pX genes were enzymatically amplified and sequenced 
      directly from DNA of five Mashhadi Jews (three with spastic myelopathy and two 
      asymptomatic carriers). Alignment and comparison of these sequences with 
      cosmopolitan and Australo-Melanesian topotypes of HTLV-I indicated that the 
      HTLV-I strains from Mashhadi Jews, which were > or = 99.9% identical among 
      themselves, exhibited considerable sequence similarity (> or = 99%) to HTLV-I 
      strains from southern India, suggesting a common source of infection. 
      Phylogenetic analysis, using the maximum parsimony method, was consistent with a 
      single-source introduction of HTLV-I into the Mashhadi Jewish community.
FAU - Nerurkar, V R
AU  - Nerurkar VR
AD  - Laboratory of Central Nervous System Studies, National Institute of Neurological 
      Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, 
      USA.
FAU - Achiron, A
AU  - Achiron A
FAU - Song, K J
AU  - Song KJ
FAU - Melland, R R
AU  - Melland RR
FAU - Pinhas-Hamiel, O
AU  - Pinhas-Hamiel O
FAU - Melamed, E
AU  - Melamed E
FAU - Shohat, B
AU  - Shohat B
FAU - Yanagihara, R
AU  - Yanagihara R
LA  - eng
SI  - GENBANK/U15767
SI  - GENBANK/U15768
SI  - GENBANK/U15769
SI  - GENBANK/U15770
SI  - GENBANK/U15771
SI  - GENBANK/U15772
SI  - GENBANK/U15773
SI  - GENBANK/U15774
SI  - GENBANK/U15775
SI  - GENBANK/U15776
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
SB  - IM
GS  - env
GS  - gag
GS  - pX
GS  - pol
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Base Sequence
MH  - Female
MH  - Genes, Viral/*genetics
MH  - Genes, env/genetics
MH  - Genes, gag/genetics
MH  - Genes, pX/genetics
MH  - Genes, pol/genetics
MH  - HTLV-I Infections/epidemiology/*virology
MH  - Heterozygote
MH  - Human T-lymphotropic virus 1/*genetics/isolation & purification
MH  - Humans
MH  - India/epidemiology
MH  - Iran/epidemiology
MH  - Jews/*genetics
MH  - Male
MH  - Molecular Sequence Data
MH  - Paraparesis, Tropical Spastic/epidemiology/*virology
MH  - Phylogeny
MH  - Sequence Homology, Nucleic Acid
EDAT- 1995/04/01 00:00
MHDA- 1995/04/01 00:01
CRDT- 1995/04/01 00:00
PHST- 1995/04/01 00:00 [pubmed]
PHST- 1995/04/01 00:01 [medline]
PHST- 1995/04/01 00:00 [entrez]
AID - 10.1002/jmv.1890450402 [doi]
PST - ppublish
SO  - J Med Virol. 1995 Apr;45(4):361-6. doi: 10.1002/jmv.1890450402.