PMID- 7666047
OWN - NLM
STAT- MEDLINE
DCOM- 19951010
LR  - 20190830
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 45
IP  - 4
DP  - 1995 Apr
TI  - Human herpesviruses 6 and 7 in salivary glands and shedding in saliva of healthy 
      and human immunodeficiency virus positive individuals.
PG  - 462-8
AB  - The presence of human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) was 
      investigated by the polymerase chain reaction in saliva specimens from healthy 
      persons, donors affected by common cold or recurrent aphthous ulceration (RAU), 
      and human immunodeficiency virus (HIV) positive patients, and in salivary gland 
      biopsies. The sensitivity of the technique made it possible to detect as few as 
      5-10 target molecules in 15 microliters of saliva. HHV-6 was present in 63% of 
      salivary gland biopsies and in 3% of salivas from healthy persons. No significant 
      difference in the presence of HHV-6 was detected in specimens from donors with 
      common cold, RAU, or HIV-infected patients. HHV-7 was present in 75% of salivary 
      glands and in 55% of salivas from healthy persons. HHV-7 was detected with 
      similar frequency in salivas from donors with common cold or RAU. Salivas from 
      HIV-infected patients harbored HHV-7 with higher frequency (81%) and increased 
      viral load. These results show that salivary glands are a site of persistent 
      infection for both HHV-6 and HHV-7. However, the two viruses seem to differ in 
      their biological properties: 1) HHV-6 is rarely present in saliva in detectable 
      amounts, while HHV-7 is frequently detected; and 2) immunosuppression by acquired 
      immunodeficiency syndrome (AIDS) increases the frequency of detection and the 
      viral load of HHV-7, but does not have a significant effect on HHV-6 shedding in 
      saliva.
FAU - Di Luca, D
AU  - Di Luca D
AD  - Institute of Microbiology, University of Ferrara, Italy.
FAU - Mirandola, P
AU  - Mirandola P
FAU - Ravaioli, T
AU  - Ravaioli T
FAU - Dolcetti, R
AU  - Dolcetti R
FAU - Frigatti, A
AU  - Frigatti A
FAU - Bovenzi, P
AU  - Bovenzi P
FAU - Sighinolfi, L
AU  - Sighinolfi L
FAU - Monini, P
AU  - Monini P
FAU - Cassai, E
AU  - Cassai E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Base Sequence
MH  - Case-Control Studies
MH  - Common Cold/complications/virology
MH  - DNA, Viral/analysis
MH  - HIV Seropositivity/*complications/virology
MH  - Herpesviridae Infections/*complications/virology
MH  - Herpesvirus 6, Human/classification/*isolation & purification
MH  - Herpesvirus 7, Human/classification/*isolation & purification
MH  - Humans
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - Saliva/*virology
MH  - Salivary Glands/*virology
MH  - Stomatitis, Aphthous/complications/virology
MH  - Virus Shedding
EDAT- 1995/04/01 00:00
MHDA- 1995/04/01 00:01
CRDT- 1995/04/01 00:00
PHST- 1995/04/01 00:00 [pubmed]
PHST- 1995/04/01 00:01 [medline]
PHST- 1995/04/01 00:00 [entrez]
AID - 10.1002/jmv.1890450418 [doi]
PST - ppublish
SO  - J Med Virol. 1995 Apr;45(4):462-8. doi: 10.1002/jmv.1890450418.