PMID- 7666455
OWN - NLM
STAT- MEDLINE
DCOM- 19951011
LR  - 20190904
IS  - 0022-2844 (Print)
IS  - 0022-2844 (Linking)
VI  - 41
IP  - 2
DP  - 1995 Aug
TI  - The genomic sequence for Prader-Willi/Angelman syndromes' loci of human is 
      apparently conserved in the great apes.
PG  - 250-2
AB  - Chromosomal changes through pericentric inversions play an important role in the 
      origin of species. Certain pericentric inversions are too minute to be detected 
      cytogenetically, thus hindering the complete reconstruction of hominoid 
      phylogeny. The advent of the fluorescence in situ hybridization (FISH) technique 
      has facilitated the identification of many chromosomal segments, even at the 
      single gene level. Therefore the cosmid probe for Prader-Willi (PWS)/Angelman 
      syndrome to the loci on human chromosome 15 [q11-13] is being used as a marker to 
      highlight the complementary sequence in higher primates. We hybridized metaphase 
      chromosomes of chimpanzee (PTR), gorilla (GGO), and orangutan (PPY) with this 
      probe (Oncor) to characterize the chromosomal segments because the nature of 
      these pericentric inversions remains relatively unknown. Our observations suggest 
      that a pericentric inversion has occurred in chimpanzee chromosome (PTR 16) which 
      corresponds to human chromosome 15 at PTR 16 band p11-12, while in gorilla (GGO 
      15) and orangutan (PPY 16) the bands q11-13 complemented to human chromosome 15 
      band q11-13. This approach has proven to be a better avenue to characterize the 
      pericentric inversions which have apparently occurred during human evolution. 
      "Genetic" divergence in the speciation process which occurs through "chromosomal" 
      rearrangement needs to be reevaluated and further explored using newer 
      techniques.
FAU - Luke, S
AU  - Luke S
FAU - Verma, R S
AU  - Verma RS
LA  - eng
PT  - Letter
PL  - Germany
TA  - J Mol Evol
JT  - Journal of molecular evolution
JID - 0360051
SB  - IM
MH  - Angelman Syndrome/*genetics
MH  - Animals
MH  - Base Sequence
MH  - Chromosome Inversion
MH  - Chromosomes, Human, Pair 15
MH  - Conserved Sequence
MH  - Hominidae/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Prader-Willi Syndrome/*genetics
EDAT- 1995/08/01 00:00
MHDA- 1995/08/01 00:01
CRDT- 1995/08/01 00:00
PHST- 1995/08/01 00:00 [pubmed]
PHST- 1995/08/01 00:01 [medline]
PHST- 1995/08/01 00:00 [entrez]
AID - 10.1007/BF00170680 [doi]
PST - ppublish
SO  - J Mol Evol. 1995 Aug;41(2):250-2. doi: 10.1007/BF00170680.