PMID- 7667208
OWN - NLM
STAT- MEDLINE
DCOM- 19951010
LR  - 20191031
IS  - 0172-8113 (Print)
IS  - 0172-8113 (Linking)
VI  - 16
IP  - 4
DP  - 1995 Jul
TI  - [Primary biliary cirrhosis. Localization of antigen-presenting cells in piecemeal 
      necroses].
PG  - 262-8
AB  - Liver tissue from 14 female patients with primary biliary cirrhosis (PBC; stages 
      I-IV) was systematically investigated for the prevalence and distribution of 
      dendritic antigen-presenting cells. Dendritic cells (DCs) were 
      immunhistochemically identified by use of anti-S 100 protein and KiMlp 
      antibodies. We confirm previous findings that, in early PBC, S 100 
      protein-positive DCs can be detected within the lining of bile duct epithelia. 
      However, the present study disclosed that S 100 protein- and KiMlp-positive DCs 
      regularly occur in piece-meal necroses (PMNs) developing in PBC-associated 
      chronic hepatitis. DCs in PMNs were observed in all PBC stages, but were most 
      prominent in late-stage PBC. These findings suggest that autoimmune tissue damage 
      in PBC may not be limited to bile ducts, but may also ensue in hepatic 
      parenchyma, producing the pattern of chronic hepatitis with signs of activity.
FAU - Zimmermann-Seydoux, G
AU  - Zimmermann-Seydoux G
AD  - Pathologisches Institut, Universitat, Bern.
FAU - Rontogianni, D
AU  - Rontogianni D
FAU - Zimmermann, A
AU  - Zimmermann A
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Primare biliare Zirrhose (PBZ). Lokalisation antigenprasentierender Zellen in 
      Piecemealnekrosen.
PL  - Germany
TA  - Pathologe
JT  - Der Pathologe
JID - 8006541
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (HLA Antigens)
RN  - 0 (S100 Proteins)
SB  - IM
MH  - Aged
MH  - Antibodies, Monoclonal
MH  - Antigen-Presenting Cells/immunology/*pathology
MH  - B-Lymphocytes/immunology/pathology
MH  - Bile Ducts, Intrahepatic/immunology/pathology
MH  - Biopsy
MH  - Dendritic Cells/immunology/*pathology
MH  - Epithelium/immunology/pathology
MH  - Female
MH  - HLA Antigens/analysis
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Liver Cirrhosis, Biliary/immunology/*pathology
MH  - Middle Aged
MH  - Necrosis
MH  - S100 Proteins/analysis
MH  - T-Lymphocytes/immunology/pathology
EDAT- 1995/07/01 00:00
MHDA- 1995/07/01 00:01
CRDT- 1995/07/01 00:00
PHST- 1995/07/01 00:00 [pubmed]
PHST- 1995/07/01 00:01 [medline]
PHST- 1995/07/01 00:00 [entrez]
AID - 10.1007/s002920050100 [doi]
PST - ppublish
SO  - Pathologe. 1995 Jul;16(4):262-8. doi: 10.1007/s002920050100.