PMID- 7667344
OWN - NLM
STAT- MEDLINE
DCOM- 19951011
LR  - 20191210
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 51
IP  - 2-3
DP  - 1995 Jun-Jul
TI  - Acute effects of methylenedioxymethamphetamine (MDMA) on several complex brain 
      functions in monkeys.
PG  - 301-7
AB  - The effects of MDMA were assessed in rhesus macaques using behavior in an operant 
      test battery (OTB) consisting of five food-reinforced tasks designed to model 
      aspects of time estimation, short-term memory, and attention, motivation, 
      learning, and color and position discrimination. Testing occurred 30 min after 
      intramuscular, injections of MDMA (0.0, 0.1, 0.3, and 1.0 mg/kg). The behavioral 
      endpoints monitored included percent task completed, response rate or latency, 
      and response accuracy. Percent task completed was significantly decreased in the 
      time estimation, learning, and motivation tasks at 1.0 mg/kg as compared to 
      saline controls. Response accuracies in the time estimation and learning tasks 
      were also decreased at 1.0 mg/kg. Response rate was decreased at 1.0 mg/kg in the 
      motivation task but was not significantly affected in any other tasks. No 
      behavioral endpoints were significantly affected in the short-term memory and 
      attention and color and position discrimination tasks at any dose tested. Results 
      indicate that time estimation, motivation, and learning are more sensitive to the 
      acute effects of MDMA than are short-term memory and attention and color and 
      position discrimination.
FAU - Frederick, D L
AU  - Frederick DL
AD  - Division of Neurotoxicology, National Center for Toxicological Research/FDA, 
      Jefferson, AR 72079-9502, USA.
FAU - Gillam, M P
AU  - Gillam MP
FAU - Allen, R R
AU  - Allen RR
FAU - Paule, M G
AU  - Paule MG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Attention/drug effects
MH  - Color Perception/drug effects
MH  - Conditioning, Operant/drug effects
MH  - Discrimination, Psychological/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Macaca mulatta
MH  - Male
MH  - Memory, Short-Term/drug effects
MH  - Mental Processes/*drug effects
MH  - Motivation
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Time Perception/drug effects
EDAT- 1995/06/01 00:00
MHDA- 1995/06/01 00:01
CRDT- 1995/06/01 00:00
PHST- 1995/06/01 00:00 [pubmed]
PHST- 1995/06/01 00:01 [medline]
PHST- 1995/06/01 00:00 [entrez]
AID - 0091-3057(94)00383-T [pii]
AID - 10.1016/0091-3057(94)00383-t [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1995 Jun-Jul;51(2-3):301-7. doi: 
      10.1016/0091-3057(94)00383-t.