PMID- 7673854
OWN - NLM
STAT- MEDLINE
DCOM- 19951019
LR  - 20190904
IS  - 0954-6820 (Print)
IS  - 0954-6820 (Linking)
VI  - 238
IP  - 3
DP  - 1995 Sep
TI  - Candidate genes for multiple endocrine neoplasia type 1.
PG  - 245-8
AB  - The aim of this study was to isolate and characterize candidates for the multiple 
      endocrine neoplasia type 1 (MEN1) gene. The development of tumours related to 
      MEN1 is associated with somatic deletions involving the MEN1 locus, suggesting 
      inactivation of a tumour-suppressor gene in this region. We have isolated five 
      cDNA candidates located within the 900 kb remaining for the MEN1 gene, determined 
      their sequence, and characterized their expression in normal tissues and several 
      endocrine tumours. One of the candidates, encoding for phospholipase C-beta 3, 
      showed properties consistent with the idea of a tumour-suppressor gene.
FAU - Lagercrantz, J
AU  - Lagercrantz J
AD  - Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
FAU - Larsson, C
AU  - Larsson C
FAU - Grimmond, S
AU  - Grimmond S
FAU - Skogseid, B
AU  - Skogseid B
FAU - Gobl, A
AU  - Gobl A
FAU - Friedman, E
AU  - Friedman E
FAU - Carson, E
AU  - Carson E
FAU - Phelan, C
AU  - Phelan C
FAU - Oberg, K
AU  - Oberg K
FAU - Nordenskjold, M
AU  - Nordenskjold M
AU  - et al.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA, Neoplasm)
RN  - EC 3.1.4.- (Type C Phospholipases)
SB  - IM
GS  - FKBP2
GS  - PLC-&bgr;3
MH  - Blotting, Northern
MH  - Chromosomes, Human, Pair 11/genetics
MH  - DNA, Complementary/analysis/isolation & purification
MH  - DNA, Neoplasm/analysis/isolation & purification
MH  - Gene Expression Regulation, Neoplastic
MH  - Genes, Tumor Suppressor/genetics
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/enzymology/*genetics
MH  - Type C Phospholipases/genetics
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 10.1111/j.1365-2796.1995.tb00930.x [doi]
PST - ppublish
SO  - J Intern Med. 1995 Sep;238(3):245-8. doi: 10.1111/j.1365-2796.1995.tb00930.x.