PMID- 7673855
OWN - NLM
STAT- MEDLINE
DCOM- 19951019
LR  - 20190904
IS  - 0954-6820 (Print)
IS  - 0954-6820 (Linking)
VI  - 238
IP  - 3
DP  - 1995 Sep
TI  - Genetic mapping of the multiple endocrine neoplasia type 1 locus at 11q13.
PG  - 249-53
AB  - Oncogenesis of tumours related to multiple endocrine neoplasia type 1 (MEN1) is 
      associated with somatic deletions involving the MEN1 locus at chromosomal region 
      11q13, suggesting inactivation of a tumour-suppressor gene in this region. Here 
      we describe the localization of the MEN1 gene to a 900-kb region, based on 
      linkage analysis in affected families and deletion mapping of MEN1-associated 
      tumours. In addition, a set of microsatellite markers mapped to the 11q11-13 
      region were used for linkage analysis in a large Tasmanian MEN1 pedigree, 
      demonstrating the usefulness of these markers for presymptomatic testing in 
      affected families.
FAU - Teh, B T
AU  - Teh BT
AD  - Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
FAU - Cardinal, J
AU  - Cardinal J
FAU - Shepherd, J
AU  - Shepherd J
FAU - Hayward, N K
AU  - Hayward NK
FAU - Weber, G
AU  - Weber G
FAU - Cameron, D
AU  - Cameron D
FAU - Larsson, C
AU  - Larsson C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
SB  - IM
MH  - Adult
MH  - *Chromosome Deletion
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Genetic Linkage
MH  - Genotype
MH  - Heterozygote
MH  - Humans
MH  - Lod Score
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Pedigree
MH  - Tasmania
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 10.1111/j.1365-2796.1995.tb00931.x [doi]
PST - ppublish
SO  - J Intern Med. 1995 Sep;238(3):249-53. doi: 10.1111/j.1365-2796.1995.tb00931.x.