PMID- 7673856
OWN - NLM
STAT- MEDLINE
DCOM- 19951019
LR  - 20190904
IS  - 0954-6820 (Print)
IS  - 0954-6820 (Linking)
VI  - 238
IP  - 3
DP  - 1995 Sep
TI  - Experience with multiple endocrine neoplasia type 1 screening.
PG  - 255-61
AB  - Screening for multiple endocrine neoplasia type 1 (MEN1) may be conducted for a 
      variety of reasons. The principal aims may be more or less scientific, such as 
      early identification of the trait. Other reasons for screening comprise attempts 
      to avoid endocrine morbidity and possibly forthcoming problems from malignant 
      transformation, as well as attempts to identify and treat gene carriers with a 
      clinically overt disease. Several reports have substantiated the diagnostic yield 
      from screening efforts among MEN1 kindreds. Such increases in detection of the 
      disease ideally should be accompanied by enhanced rates of survival in order to 
      fully justify an unlimited search for the trait. However, studies are lacking a 
      clearly verifying reduction of mortality from the detection of presymptomatic 
      MEN1 individuals. While waiting for the results of survival studies in progress, 
      the generally prevailing opinion favours widespread screening because of the 
      evidently decreased morbidity resulting from early diagnosis of the MEN1 trait, 
      which apparently persists even during decades of follow-up. This paper presents 
      the clinical features of the disease and experience derived from a prospective 
      screening programme for MEN1 detection.
FAU - Skogseid, B
AU  - Skogseid B
AD  - Department of Internal Medicine University Hospital, Uppsala, Sweden.
FAU - Oberg, K
AU  - Oberg K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
SB  - IM
MH  - Cell Transformation, Neoplastic
MH  - Decision Trees
MH  - Endocrine System Diseases/genetics/*prevention & control
MH  - Heterozygote
MH  - Humans
MH  - *Mass Screening
MH  - Multiple Endocrine Neoplasia Type 1/complications/*diagnosis
MH  - Prospective Studies
MH  - Survival Analysis
RF  - 28
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 10.1111/j.1365-2796.1995.tb00932.x [doi]
PST - ppublish
SO  - J Intern Med. 1995 Sep;238(3):255-61. doi: 10.1111/j.1365-2796.1995.tb00932.x.