PMID- 7673857
OWN - NLM
STAT- MEDLINE
DCOM- 19951019
LR  - 20190904
IS  - 0954-6820 (Print)
IS  - 0954-6820 (Linking)
VI  - 238
IP  - 3
DP  - 1995 Sep
TI  - Multiple endocrine neoplasia type 1 in France: clinical and genetic studies.
PG  - 263-8
AB  - Multiple endocrine neoplasia type 1 (MEN1) is a hereditary syndrome characterized 
      by the involvement of several endocrine glands, including the parathyroid glands, 
      the pancreatic islet cells, the anterior pituitary gland and other neuroendocrine 
      tissues. In order to build up a French MEN1 register, a collaborative network was 
      developed through the 'Groupe d'Etude des Neoplasies Endocriniennes Multiples de 
      type 1' or GENEM 1. A 2-year follow-up in 40 medical and surgical units allowed 
      the identification of more than 150 individual patients and 45 MEN1 families, and 
      defined the major clinical features of the disease in our series. Multiple 
      endocrine neoplasia type 1 is inherited as an autosomal dominant trait. The gene 
      causing this syndrome has been localized to chromosome 11, band 11q13, and 
      molecular genetic markers flanking the MEN1 locus are of use in identifying 
      disease gene carriers in predisposed families. Selected data were presented in 
      order to discuss the management of patients by combined clinical, biochemical and 
      genetic screening. The set-up of a national register by a multi-disciplinary and 
      collaborative medical and surgical network will facilitate further research on 
      the clinical management of MEN1 patients and the basic physio-pathology of the 
      disease.
FAU - Calender, A
AU  - Calender A
AD  - Department of Genetics, Edouard Herriot Hospital, Lyon, France.
FAU - Giraud, S
AU  - Giraud S
FAU - Cougard, P
AU  - Cougard P
FAU - Chanson, P
AU  - Chanson P
FAU - Lenoir, G
AU  - Lenoir G
FAU - Murat, A
AU  - Murat A
FAU - Hamon, P
AU  - Hamon P
FAU - Proye, C
AU  - Proye C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Female
MH  - France/epidemiology
MH  - Heterozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Multiple Endocrine Neoplasia Type 1/diagnosis/epidemiology/genetics/therapy
MH  - Pedigree
MH  - Registries
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 10.1111/j.1365-2796.1995.tb00933.x [doi]
PST - ppublish
SO  - J Intern Med. 1995 Sep;238(3):263-8. doi: 10.1111/j.1365-2796.1995.tb00933.x.