PMID- 7673858
OWN - NLM
STAT- MEDLINE
DCOM- 19951019
LR  - 20190904
IS  - 0954-6820 (Print)
IS  - 0954-6820 (Linking)
VI  - 238
IP  - 3
DP  - 1995 Sep
TI  - The surgical management of hyperparathyroidism and endocrine disease of the 
      pancreas in the multiple endocrine neoplasia type 1 patient.
PG  - 269-80
AB  - The surgical management of multiple endocrine neoplasia type 1 (MEN1) parathyroid 
      disease and involvement of the endocrine pancreas remains controversial. 
      Hyperparathyroidism, usually the first clinical manifestation of the syndrome, 
      requires surgical treatment in nearly all patients. We favour a subtotal 
      parathyroidectomy and cervical thymectomy rather than a total parathyroidectomy 
      and autotransplant because of good long-term results and the absence of permanent 
      hypoparathyroidism. The results of treating 34 MEN1 patients during a 20-year 
      period are reported. The most common functional pancreatic or duodenal tumours in 
      MEN1 patients are gastrinomas and insulinomas. In addition to the management of 
      functional syndromes, another major concern is the malignant potential of the 
      neuroendocrine tumours that frequently develop. Our surgical management of 
      gastrinomas and the ZES has evolved over a period of 15 years. We have found that 
      distal pancreatectomy, enucleation of any neoplasms in the head, and duodenotomy 
      and excision of any neuroendocrine tumours (gastrinomas) combined with a regional 
      node dissection are effective in the majority of patients. The results of 
      treating 21 MEN1 patients with ZES are reported.
FAU - Thompson, N W
AU  - Thompson NW
AD  - University of Michigan, Department of Surgery, Ann Arbor, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
SB  - IM
MH  - Adult
MH  - Algorithms
MH  - Duodenal Neoplasms/surgery
MH  - Female
MH  - Gastrinoma/surgery
MH  - Humans
MH  - Hyperparathyroidism/genetics/*surgery
MH  - Insulinoma/surgery
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*complications
MH  - Pancreatic Neoplasms/genetics/*surgery
MH  - Retrospective Studies
MH  - Zollinger-Ellison Syndrome/genetics/*surgery
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 10.1111/j.1365-2796.1995.tb00934.x [doi]
PST - ppublish
SO  - J Intern Med. 1995 Sep;238(3):269-80. doi: 10.1111/j.1365-2796.1995.tb00934.x.