PMID- 7673859
OWN - NLM
STAT- MEDLINE
DCOM- 19951019
LR  - 20190904
IS  - 0954-6820 (Print)
IS  - 0954-6820 (Linking)
VI  - 238
IP  - 3
DP  - 1995 Sep
TI  - Operative tumour yield obviates preoperative pancreatic tumour localization in 
      multiple endocrine neoplasia type 1.
PG  - 281-8
AB  - The efficiency of pancreatic tumour localization was prospectively evaluated in 
      12 consecutive patients with multiple endocrine neoplasia type 1 (MEN1), who were 
      subjected to extirpation of 56 islet cell neoplasms of 0.2-4 cm in diameter (mean 
      0.8 cm) during pancreatic resection and enucleation. Computed tomography, 
      angiography of the coeliac trunc and superior mesenteric artery, and percutaneous 
      ultrasound correctly localized 7-12% of the tumours and 21-37% of the 19 lesions 
      measuring at least one centimetre in diameter. Transhepatic portal vein sampling 
      correctly located tumour sites in the proximal or distal portions of the pancreas 
      in four out of six patients, but demonstrated unsatisfactory specificity. 
      Intra-operative ultrasound and bidigital palpation of the pancreas had overall 
      sensitivities of 86 and 45%, respectively, and eight lesions below 0.3 cm in 
      diameter remained undetected with intraoperative ultrasound. It is concluded that 
      diagnosis of endocrine pancreatic neoplasms is biochemical in MEN1 and that broad 
      screening of tumour markers efficiently reveals pancreatic involvement decades 
      before the development of a clinically overt disease. Intra-operative ultrasound 
      is a requisite for pancreatic endocrine surgery in MEN1, and it obviates the need 
      for conventional pancreatic imaging unless a pre-operative search for metastatic 
      disease and anatomical aberrations is considered important.
FAU - Skogseid, B
AU  - Skogseid B
AD  - Department of Internal Medicine, University Hospital, Uppsala, Sweden.
FAU - Grama, D
AU  - Grama D
FAU - Rastad, J
AU  - Rastad J
FAU - Eriksson, B
AU  - Eriksson B
FAU - Lindgren, P G
AU  - Lindgren PG
FAU - Ahlstrom, H
AU  - Ahlstrom H
FAU - Lorelius, L E
AU  - Lorelius LE
FAU - Wilander, E
AU  - Wilander E
FAU - Akerstrom, G
AU  - Akerstrom G
FAU - Oberg, K
AU  - Oberg K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*complications
MH  - Palpation
MH  - Pancreatic Neoplasms/*diagnosis/genetics/*surgery
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Tomography, X-Ray Computed
MH  - Ultrasonography/methods
EDAT- 1995/09/01 00:00
MHDA- 1995/09/01 00:01
CRDT- 1995/09/01 00:00
PHST- 1995/09/01 00:00 [pubmed]
PHST- 1995/09/01 00:01 [medline]
PHST- 1995/09/01 00:00 [entrez]
AID - 10.1111/j.1365-2796.1995.tb00935.x [doi]
PST - ppublish
SO  - J Intern Med. 1995 Sep;238(3):281-8. doi: 10.1111/j.1365-2796.1995.tb00935.x.