PMID- 7676647
OWN - NLM
STAT- MEDLINE
DCOM- 19951013
LR  - 20061115
IS  - 0042-6822 (Print)
IS  - 0042-6822 (Linking)
VI  - 212
IP  - 1
DP  - 1995 Sep 10
TI  - Molecular comparison of coxsackie A virus serotypes.
PG  - 30-8
AB  - Genetic diversity of coxsackie A viruses (CAVs) and enteroviruses 68, 69, and 71 
      was studied by comparing nucleotide and derived amino acid sequences from the 5' 
      untranslated region (5'UTR), VP4-VP2 capsid protein and polymerase 3D region, and 
      3'UTR. The data were obtained by sequencing PCR amplicons. According to the 
      molecular analysis of the coding region, CAVs belong to three different genetic 
      clusters. CAV2, 3, 5, 7, 8, 10, 12, 14, and 16 form a coherent genetic group 
      designated cluster A. No other enteroviruses, apart from enterovirus 71, are 
      found in this cluster. CAV9 is the only member of the subgroup found in the same 
      genetic group with coxsackie B viruses, the major group of echoviruses and 
      enterovirus 69 (cluster B). Cluster C includes CAV1, 11, 13, 15, 17, 18, 19, 20, 
      21, 22, and 24 which are genetically close relatives of polioviruses. Enterovirus 
      68 is related to enterovirus 70 (cluster D). Clusters different from those in the 
      coding region are found in the 5'UTR while the grouping in the 3'UTR is similar 
      to that found in the capsid region. Correlation of these findings with evolution, 
      pathogenesis, and classification is discussed.
FAU - Pulli, T
AU  - Pulli T
AD  - Department of Virology, University of Turku, Finland.
FAU - Koskimies, P
AU  - Koskimies P
FAU - Hyypia, T
AU  - Hyypia T
LA  - eng
SI  - GENBANK/X87584
SI  - GENBANK/X87585
SI  - GENBANK/X87586
SI  - GENBANK/X87587
SI  - GENBANK/X87588
SI  - GENBANK/X87589
SI  - GENBANK/X87590
SI  - GENBANK/X87591
SI  - GENBANK/X87592
SI  - GENBANK/X87593
SI  - GENBANK/X87594
SI  - GENBANK/X87595
SI  - GENBANK/X87596
SI  - GENBANK/X87597
SI  - GENBANK/X87598
SI  - GENBANK/X87599
SI  - GENBANK/X87600
SI  - GENBANK/X87601
SI  - GENBANK/X87602
SI  - GENBANK/X87603
SI  - GENBANK/X87604
SI  - GENBANK/X87605
SI  - GENBANK/X87606
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (DNA Primers)
RN  - 0 (RNA, Viral)
RN  - 0 (Viral Structural Proteins)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Base Sequence
MH  - DNA Primers/chemistry
MH  - Enterovirus/*classification/genetics
MH  - Genes, Viral
MH  - Intercellular Adhesion Molecule-1/metabolism
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - RNA, Viral/genetics
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Sequence Homology, Nucleic Acid
MH  - Serotyping
MH  - Viral Structural Proteins/genetics
EDAT- 1995/09/10 00:00
MHDA- 1995/09/10 00:01
CRDT- 1995/09/10 00:00
PHST- 1995/09/10 00:00 [pubmed]
PHST- 1995/09/10 00:01 [medline]
PHST- 1995/09/10 00:00 [entrez]
AID - S0042-6822(85)71450-X [pii]
AID - 10.1006/viro.1995.1450 [doi]
PST - ppublish
SO  - Virology. 1995 Sep 10;212(1):30-8. doi: 10.1006/viro.1995.1450.