PMID- 7677228
OWN - NLM
STAT- MEDLINE
DCOM- 19951019
LR  - 20190821
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 50
IP  - 25 Suppl
DP  - 1995
TI  - T cell receptor-V beta repertoire in allergen-specific sensitization and 
      increased airway responsiveness.
PG  - 15-9
AB  - An animal model system was developed to study the mechanisms resulting in 
      allergic sensitization. Local allergen exposure via the airways and the lung 
      stimulated an allergen-specific immunoglobulin E (IgE) response that was 
      paralleled by the development of increased airway responsiveness (AR). It was 
      found that CD4+ T cells of local draining lymph nodes played an important role in 
      the regulation of these events. Stimulation of allergen-specific T cells requires 
      interaction between major histocompatibility complex (MHC) class II molecules 
      (expressed on antigen-presenting cells), peptide (presented on MHC) and the T 
      cell receptor. Allergen sensitization stimulated T cells that expressed a 
      restricted T cell receptor V beta (TCR-V beta) elements. Each allergen stimulated 
      different V beta elements, and sensitization to the same allergen resulted in a 
      different pattern of TCR-V beta stimulation in different lymphoid tissues. Some 
      of these T cells had pro-allergenic effects, whereas others were able to inhibit 
      the development of the allergic response, including the development of increased 
      AR. These data indicate that the local T cell response regulates the type of 
      immune response that evolves following local allergen sensitization.
FAU - Renz, H
AU  - Renz H
AD  - Institut fur Klinische Chemie und Biochemie, Freie Universitat Berlin, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
SB  - IM
MH  - Allergens/*immunology
MH  - Animals
MH  - Hypersensitivity/immunology/physiopathology
MH  - *Immunization
MH  - Mice
MH  - Models, Immunological
MH  - Receptors, Antigen, T-Cell, alpha-beta/*metabolism
MH  - Respiratory System/*immunology/*physiopathology
MH  - T-Lymphocytes/physiology
RF  - 35
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1111/j.1398-9995.1995.tb04269.x [doi]
PST - ppublish
SO  - Allergy. 1995;50(25 Suppl):15-9. doi: 10.1111/j.1398-9995.1995.tb04269.x.