PMID- 7677233
OWN - NLM
STAT- MEDLINE
DCOM- 19951019
LR  - 20190821
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 50
IP  - 25 Suppl
DP  - 1995
TI  - The role of CD8+ T cells in immunoglobulin E regulation.
PG  - 9-14
AB  - The link between immunoglobulin E (IgE) antibodies and environmental allergens, 
      allergic sensitization and atopic diseases such as asthma, rhinitis and eczema is 
      well established, yet treatment of these diseases is largely symptomatic and 
      fails to correct the underlying immune disorder. B-cell production of IgE depends 
      on interleukin 4 (IL-4) and is inhibited by interferon (IFN-gamma). These 
      cytokines are produced by T-helper 2 (Th2) and T-helper 1 (Th1) CD4+ T cells 
      respectively. In atopic dermatitis skin and asthmatic lung, Th2 cells predominate 
      but antigen-specific CD4+ T-cell clones derived from peripheral blood are a 
      mixture of Th1, Th2, and Th0. Circulating allergen-specific CD4+ T cells 
      differentiate into Th1- and Th2-like clones in the presence of IL-12 and IL-4 
      respectively. In rats, CD8+ T cells are potent regulators of IgE responses in 
      vivo, although the mechanism for this is still unclear. CD8+ T-cell depletion in 
      immunized animals prolonged the IgE response but prior depletion did not. Indeed, 
      prior depletion of CD8+ T cells actually inhibited IgE production, suggesting 
      that there may be more than one type of IgE regulatory CD8+ T cell. This was 
      supported by the observation that CD8+ T cells inhibited the differentiation of 
      both Th1 and Th2 CD4+ T cells in vitro as well as IL-4- but not IL-2-induced Th2 
      CD4+ T-cell growth. The existence of distinct CD8+ T-cell subsets is supported by 
      the observation that IL-4 and IFN-gamma regulate the growth and differentiation 
      of CD8+ T cells.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Kemeny, D M
AU  - Kemeny DM
AD  - Department of Allergy and Respiratory Medicine, UMDS, Guy's and St Thomas's 
      Hospital, London, United Kingdom.
FAU - NOble, A
AU  - NOble A
FAU - Holmes, B J
AU  - Holmes BJ
FAU - Diaz-Sanchez, D
AU  - Diaz-Sanchez D
FAU - Lee, T H
AU  - Lee TH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Isoantibodies)
RN  - 0 (anti-Thy antibody)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/cytology/immunology
MH  - CD8-Positive T-Lymphocytes/cytology/*physiology
MH  - Cell Differentiation
MH  - Cell Division
MH  - Humans
MH  - Immunoglobulin E/*physiology
MH  - Isoantibodies/analysis
MH  - Models, Immunological
RF  - 31
EDAT- 1995/01/01 00:00
MHDA- 1995/01/01 00:01
CRDT- 1995/01/01 00:00
PHST- 1995/01/01 00:00 [pubmed]
PHST- 1995/01/01 00:01 [medline]
PHST- 1995/01/01 00:00 [entrez]
AID - 10.1111/j.1398-9995.1995.tb04268.x [doi]
PST - ppublish
SO  - Allergy. 1995;50(25 Suppl):9-14. doi: 10.1111/j.1398-9995.1995.tb04268.x.