PMID- 7678183
OWN - NLM
STAT- MEDLINE
DCOM- 19930203
LR  - 20240109
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 259
IP  - 5091
DP  - 1993 Jan 1
TI  - Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked 
      insulin resistance.
PG  - 87-91
AB  - Tumor necrosis factor-alpha (TNF-alpha) has been shown to have certain catabolic 
      effects on fat cells and whole animals. An induction of TNF-alpha messenger RNA 
      expression was observed in adipose tissue from four different rodent models of 
      obesity and diabetes. TNF-alpha protein was also elevated locally and 
      systemically. Neutralization of TNF-alpha in obese fa/fa rats caused a 
      significant increase in the peripheral uptake of glucose in response to insulin. 
      These results indicate a role for TNF-alpha in obesity and particularly in the 
      insulin resistance and diabetes that often accompany obesity.
FAU - Hotamisligil, G S
AU  - Hotamisligil GS
AD  - Dana-Farber Cancer Institute, Boston, MA.
FAU - Shargill, N S
AU  - Shargill NS
FAU - Spiegelman, B M
AU  - Spiegelman BM
LA  - eng
GR  - DK 42539/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Blood Glucose)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Insulin)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 63231-63-0 (RNA)
RN  - W81N5U6R6U (Sodium Glutamate)
SB  - IM
MH  - 3T3 Cells
MH  - Adipose Tissue/physiology/*physiopathology
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Blotting, Northern
MH  - Diabetes Mellitus, Experimental/physiopathology
MH  - Glucose Clamp Technique
MH  - Homeostasis
MH  - Immunoglobulin G/genetics/pharmacology
MH  - Insulin/pharmacology
MH  - Insulin Infusion Systems
MH  - Insulin Resistance/*genetics
MH  - Male
MH  - Mice
MH  - Mice, Obese
MH  - Obesity/chemically induced/*genetics/*physiopathology
MH  - RNA/genetics/isolation & purification
MH  - RNA, Messenger/*biosynthesis/isolation & purification
MH  - Rats
MH  - Rats, Zucker
MH  - Receptors, Cell Surface/genetics/physiology
MH  - Receptors, Tumor Necrosis Factor
MH  - Recombinant Fusion Proteins/pharmacology
MH  - Reference Values
MH  - Sodium Glutamate
MH  - Tumor Necrosis Factor-alpha/biosynthesis/*genetics
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1126/science.7678183 [doi]
PST - ppublish
SO  - Science. 1993 Jan 1;259(5091):87-91. doi: 10.1126/science.7678183.