PMID- 7678672
OWN - NLM
STAT- MEDLINE
DCOM- 19930225
LR  - 20190724
IS  - 0160-2446 (Print)
IS  - 0160-2446 (Linking)
VI  - 21
IP  - 1
DP  - 1993 Jan
TI  - GABA and bicuculline-induced blood pressure changes in spontaneously hypertensive 
      rats.
PG  - 156-62
AB  - The brain GABAergic system was previously shown to influence blood pressure (BP) 
      maintenance in rats which may in part be accomplished by disruption of the 
      central renin-angiotensin system (RAS). We examined the potential role of GABA in 
      sustaining the high BP exhibited by the spontaneously hypertensive rat (SHR) 
      model of human essential hypertension. Intracerebroventricular (i.c.v.) infusion 
      of GABA produced decreases in BP in members of three rat strains, including 
      Wistar-Kyoto (WKY) and Sprague-Dawley normotensive controls and SHR. The SHR were 
      significantly more sensitive to GABA than the normotensive strains. Next, the 
      GABA receptor antagonist bicuculline (BMI) was infused i.c.v. and produced 
      increases in BP in members of each strain. Finally, i.c.v. pretreatment with the 
      specific angiotensin receptor antagonist [Sar1, Thr8]AII (sarthran), blocked 
      subsequent GABA-induced decreases in BP in members of all three strains, and 
      there was a trend toward sarthran attenuation of BMI-induced increases in BP. 
      These results encourage the hypothesis that the hypotensive effects produced by 
      central application of GABA are mediated by the brain angiotensin system.
FAU - Roberts, K A
AU  - Roberts KA
AD  - Department of Psychology, Washington State University, Pullman 99164-4820.
FAU - Wright, J W
AU  - Wright JW
FAU - Harding, J W
AU  - Harding JW
LA  - eng
GR  - HL-32063/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Cardiovasc Pharmacol
JT  - Journal of cardiovascular pharmacology
JID - 7902492
RN  - 11128-99-7 (Angiotensin II)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 56832-47-4 (angiotensin II, Sar(1)-Thr(8)-)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Analysis of Variance
MH  - Angiotensin II/analogs & derivatives/antagonists & inhibitors/pharmacology
MH  - Animals
MH  - Bicuculline/*pharmacology
MH  - Blood Pressure/*drug effects
MH  - Drug Interactions
MH  - Hypertension/*drug therapy/physiopathology
MH  - Injections, Intraventricular
MH  - Male
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Rats, Sprague-Dawley
MH  - gamma-Aminobutyric Acid/administration & dosage/metabolism/*pharmacology
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1097/00005344-199301000-00023 [doi]
PST - ppublish
SO  - J Cardiovasc Pharmacol. 1993 Jan;21(1):156-62. doi: 
      10.1097/00005344-199301000-00023.