PMID- 7678852
OWN - NLM
STAT- MEDLINE
DCOM- 19930302
LR  - 20190512
IS  - 0022-3069 (Print)
IS  - 0022-3069 (Linking)
VI  - 52
IP  - 1
DP  - 1993 Jan
TI  - Hirano bodies accumulate C-terminal sequences of beta-amyloid precursor protein 
      (beta-APP) epitopes.
PG  - 14-21
AB  - Hirano bodies (HB) are cytoplasmic inclusions predominantly found in the CA1 
      sector of the hippocampus. In Alzheimer's disease they are dislocated to the 
      stratum pyramidale from their normal position in the stratum lacunosum. Hirano 
      bodies are known to contain epitopes related to microfilaments (actin), 
      neurofilaments, and microtubules (tau). In cryostat sections of the hippocampus 
      from both Alzheimer's disease and normal patients, HB were decorated by two 
      antisera raised against different sequences of the cytoplasmic domain of 
      beta-amyloid precursor protein (beta-APP), and two antisera against the beta/A4 
      sequence of beta-APP, but not by two antisera directed against ectodomain 
      (N-terminal) sequences of beta-APP. Thus, in contrast to dystrophic neurites in 
      plaques, which are decorated by antibodies to either terminus of beta-APP, HB 
      appear to be a site of preferential accumulation of C-terminal fragments of 
      beta-APP, extending to include at least part of beta/A4.
FAU - Munoz, D G
AU  - Munoz DG
AD  - Department of Pathology, University of Western Ontario, London, Canada.
FAU - Wang, D
AU  - Wang D
FAU - Greenberg, B D
AU  - Greenberg BD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neuropathol Exp Neurol
JT  - Journal of neuropathology and experimental neurology
JID - 2985192R
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Epitopes)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/*metabolism
MH  - Alzheimer Disease/*metabolism/pathology
MH  - Amyloid beta-Protein Precursor/*analysis/immunology
MH  - Epitopes/*analysis
MH  - Hippocampus/*chemistry/pathology
MH  - Humans
MH  - Nervous System Diseases/metabolism/pathology
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 1993/01/01 00:00
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
PHST- 1993/01/01 00:00 [entrez]
AID - 10.1097/00005072-199301000-00003 [doi]
PST - ppublish
SO  - J Neuropathol Exp Neurol. 1993 Jan;52(1):14-21. doi: 
      10.1097/00005072-199301000-00003.