PMID- 7679328
OWN - NLM
STAT- MEDLINE
DCOM- 19930316
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 72
IP  - 3
DP  - 1993 Feb 12
TI  - Molecular cloning, functional expression, and signaling characteristics of a C-C 
      chemokine receptor.
PG  - 415-25
AB  - The immunoregulatory proteins C-C chemokines are potent chemoattractants of 
      lymphocytes and monocytes, as well as activators and attractants of eosinophils 
      and basophils. We have isolated a cDNA that encodes a seven 
      transmembrane-spanning receptor, with homology to other chemoattractant 
      receptors, that encodes a protein designated C-C CKR-1 that acts as a receptor 
      for the C-C chemokines. Human and murine macrophage inflammatory protein 1 alpha 
      (MIP-1 alpha), human human monocyte chemotactic protein 1 (MCP-1), and RANTES all 
      bind to the C-C CKR-1 with varying affinities. Chemokine binding affinity does 
      not predict how well the ligand will transmit a signal through the receptor: 
      RANTES and human MIP-1 alpha induce a similar intracellular calcium flux while 
      binding with disparate affinities, while MCP-1 and human MIP-1 beta induce 
      calcium mobilization only at high concentrations. Finally, C-C chemokines were 
      shown to bind a C-C CKR-1-related gene product encoded by cytomegalovirus, 
      suggesting a role for C-C chemokines in viral immunity.
FAU - Neote, K
AU  - Neote K
AD  - Department of Immunology, Genentech, Incorporated, South San Francisco, 
      California 94080.
FAU - DiGregorio, D
AU  - DiGregorio D
FAU - Mak, J Y
AU  - Mak JY
FAU - Horuk, R
AU  - Horuk R
FAU - Schall, T J
AU  - Schall TJ
LA  - eng
SI  - GENBANK/L09230
SI  - GENBANK/L20501
SI  - GENBANK/L33702
SI  - GENBANK/L33703
SI  - GENBANK/L33704
SI  - GENBANK/L33705
SI  - GENBANK/L33706
SI  - GENBANK/L33707
SI  - GENBANK/L33708
SI  - GENBANK/L33709
SI  - GENBANK/M99293
SI  - GENBANK/X17403
PT  - Journal Article
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Cytokines)
RN  - 0 (Lymphokines)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (Monokines)
RN  - 0 (Oligopeptides)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Viral Proteins)
RN  - 0 (Viral Structural Proteins)
RN  - 9007-49-2 (DNA)
RN  - SY7Q814VUP (Calcium)
SB  - IM
GS  - C5AR
GS  - CKR-1
GS  - FMLPR
GS  - IL8RA
GS  - IL8RB
GS  - STSR
MH  - Amino Acid Sequence
MH  - Binding, Competitive
MH  - Calcium/physiology
MH  - Cells, Cultured
MH  - Chemokine CCL3
MH  - Chemokine CCL4
MH  - Chemokine CCL5
MH  - Cloning, Molecular
MH  - Cytokines/*physiology
MH  - Cytomegalovirus/metabolism
MH  - DNA/genetics
MH  - Genes, Viral
MH  - Humans
MH  - In Vitro Techniques
MH  - Lymphokines/*physiology
MH  - Macrophage Inflammatory Proteins
MH  - Molecular Sequence Data
MH  - Monokines/*physiology
MH  - Oligopeptides/chemistry
MH  - Open Reading Frames
MH  - Receptors, Cell Surface/*genetics/physiology
MH  - Sequence Alignment
MH  - Signal Transduction
MH  - Viral Proteins/metabolism
MH  - Viral Structural Proteins/genetics
EDAT- 1993/02/12 00:00
MHDA- 1993/02/12 00:01
CRDT- 1993/02/12 00:00
PHST- 1993/02/12 00:00 [pubmed]
PHST- 1993/02/12 00:01 [medline]
PHST- 1993/02/12 00:00 [entrez]
AID - 0092-8674(93)90118-A [pii]
AID - 10.1016/0092-8674(93)90118-a [doi]
PST - ppublish
SO  - Cell. 1993 Feb 12;72(3):415-25. doi: 10.1016/0092-8674(93)90118-a.