PMID- 7681936
OWN - NLM
STAT- MEDLINE
DCOM- 19930430
LR  - 20171116
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 362
IP  - 6419
DP  - 1993 Apr 1
TI  - Infection of natural killer cells by human herpesvirus 6.
PG  - 458-62
AB  - Natural killer (NK) cells are a functionally defined subset of non-T, non-B 
      lymphocytes of bone marrow origin, which induce lysis of selected target cells, 
      including neoplastic and virus-infected cells. The NK cell function provides an 
      important mechanism of primary defence against viruses in vivo, as demonstrated 
      by the occurrence of multiple herpesvirus infections in patients congenitally 
      lacking NK cells. Here we show that functionally competent CD3- NK clones can be 
      productively infected by human herpesvirus 6 (HHV-6), a T-lymphotropic DNA virus 
      that may play a role in the acquired immunodeficiency syndrome (AIDS) and in the 
      chronic fatigue syndrome, two disorders associated with a defective NK cell 
      activity. The infection is cytopathic and induces de novo expression of CD4, an 
      antigen not expressed within the NK lineage, thereby predisposing NK cells to 
      infection by human immunodeficiency virus type 1 (HIV-1). These results provide 
      evidence that a herpesvirus can directly target and kill NK cells, a potential 
      strategy to suppress the natural anti-viral immunity of the host.
FAU - Lusso, P
AU  - Lusso P
AD  - Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes 
      of Health, Bethesda, Maryland 20892.
FAU - Malnati, M S
AU  - Malnati MS
FAU - Garzino-Demo, A
AU  - Garzino-Demo A
FAU - Crowley, R W
AU  - Crowley RW
FAU - Long, E O
AU  - Long EO
FAU - Gallo, R C
AU  - Gallo RC
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (CD3 Complex)
RN  - 0 (CD4 Antigens)
RN  - 0 (CD56 Antigen)
RN  - 0 (Oligodeoxyribonucleotides)
RN  - 0 (Oligonucleotide Probes)
SB  - IM
MH  - Adult
MH  - Antigens, CD/analysis
MH  - Antigens, Differentiation, T-Lymphocyte/analysis
MH  - Base Sequence
MH  - CD3 Complex/analysis
MH  - CD4 Antigens/biosynthesis
MH  - CD56 Antigen
MH  - Cell Line
MH  - Cells, Cultured
MH  - Flow Cytometry
MH  - Herpesvirus 6, Human/genetics/*immunology/isolation & purification
MH  - Humans
MH  - Killer Cells, Natural/immunology/*microbiology/ultrastructure
MH  - Microscopy, Electron
MH  - Molecular Sequence Data
MH  - Oligodeoxyribonucleotides
MH  - Oligonucleotide Probes
MH  - Polymerase Chain Reaction/methods
EDAT- 1993/04/01 00:00
MHDA- 1993/04/01 00:01
CRDT- 1993/04/01 00:00
PHST- 1993/04/01 00:00 [pubmed]
PHST- 1993/04/01 00:01 [medline]
PHST- 1993/04/01 00:00 [entrez]
AID - 10.1038/362458a0 [doi]
PST - ppublish
SO  - Nature. 1993 Apr 1;362(6419):458-62. doi: 10.1038/362458a0.