PMID- 7684907
OWN - NLM
STAT- MEDLINE
DCOM- 19930701
LR  - 20071114
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 193
IP  - 1
DP  - 1993 May 28
TI  - The mitochondrial aldehyde dehydrogenase gene resides in an HTF island but is 
      expressed in a tissue-specific manner.
PG  - 420-7
AB  - The tissue distribution of mitochondrial aldehyde dehydrogenase (ALDH2) in rats 
      was analyzed by activity assays, and by Western and Northern blotting. ALDH2 was 
      expressed at highest levels in liver. The mRNA levels were intermediate in the 
      kidney and lung, while lower levels were found in spleen and heart. The 
      transcript was undetectable in other tissues tested. The human ALDH2 5' flanking 
      region (-200 to +60) contains similar numbers of CpG and GpC dinucleotides and 
      the rat ALDH2 gene was undermethylated in liver, kidney, and spleen. This 
      suggests that the ALDH2 promoter resides in a Hpa II tiny fragment (HTF) island, 
      unlike most genes expressed in a tissue-specific manner.
FAU - Dipple, K M
AU  - Dipple KM
AD  - Department of Medicine, Indiana University School of Medicine, Indianapolis 
      46202-5121.
FAU - Crabb, D W
AU  - Crabb DW
LA  - eng
GR  - F30 05310/PHS HHS/United States
GR  - K02 00081/PHS HHS/United States
GR  - R37 06434/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (RNA, Messenger)
RN  - EC 1.2.1.3 (Aldehyde Dehydrogenase)
RN  - EC 3.1.21.- (Deoxyribonuclease HpaII)
RN  - EC 3.1.21.4 (Deoxyribonucleases, Type II Site-Specific)
SB  - IM
GS  - ALDH2
MH  - Aldehyde Dehydrogenase/*genetics
MH  - Animals
MH  - Deoxyribonuclease HpaII
MH  - Deoxyribonucleases, Type II Site-Specific
MH  - Intestines/enzymology
MH  - Kidney/enzymology
MH  - Lung/enzymology
MH  - Mitochondria, Liver/*enzymology
MH  - Myocardium/enzymology
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Spleen/enzymology
MH  - Stomach/enzymology
EDAT- 1993/05/28 00:00
MHDA- 1993/05/28 00:01
CRDT- 1993/05/28 00:00
PHST- 1993/05/28 00:00 [pubmed]
PHST- 1993/05/28 00:01 [medline]
PHST- 1993/05/28 00:00 [entrez]
AID - S0006-291X(83)71640-2 [pii]
AID - 10.1006/bbrc.1993.1640 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1993 May 28;193(1):420-7. doi: 
      10.1006/bbrc.1993.1640.