PMID- 7685472
OWN - NLM
STAT- MEDLINE
DCOM- 19930715
LR  - 20190920
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 15
IP  - 2
DP  - 1993 Mar-Apr
TI  - Oral administration of 3,4-methylenedioxymethamphetamine (MDMA) produces 
      selective serotonergic depletion in the nonhuman primate.
PG  - 91-6
AB  - MDMA (3,4-methylenedioxymethamphetamine) has been reported to produce 
      serotonergic depletion in nonhuman primates at doses as low as 2.5 mg/kg (1-2 
      times the typical human dose). The current study evaluated the dose-response 
      relationships of MDMA (1.25-20.0 mg/kg) using regional concentrations of 
      serotonin (5-HT) and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA), and 
      home cage behavior as endpoints. Adult female rhesus monkeys (n = 16) were 
      treated orally with 0, 1.25, 2.5, or 20.0 mg/kg MDMA twice daily for 4 
      consecutive days. Eighteen behaviors were measured in the home cage prior to, 
      during, and after MDMA treatment. One month after the last dose, the animals were 
      sacrificed and brains dissected into several regions for neurochemical analyses. 
      5-HT and 5-HIAA were analyzed via HPLC/EC. The lower doses of MDMA (1.25 and 2.5 
      mg/kg) did not significantly alter 5-HT or 5-HIAA concentrations in any brain 
      region except hippocampus in which 5-HT concentrations were decreased after 2.5 
      mg/kg. MDMA at 20.0 mg/kg significantly decreased 5-HT and 5-HIAA concentrations 
      in several cortical and midbrain structures. However, 5-HT and 5-HIAA 
      concentrations in brain stem and hypothalamus were not significantly altered 
      after any dose of MDMA. Combined with previous data from this laboratory, these 
      results indicate that the decreased concentrations of 5-HT and 5-HIAA in selected 
      brain regions show a selective dose-response relationship for MDMA-induced 
      neurotoxicity as measured by serotonergic depletion in the nonhuman primate.
FAU - Ali, S F
AU  - Ali SF
AD  - Division of Neurotoxicology, National Center for Toxicological Research, 
      Jefferson, AR 72079-9502.
FAU - Newport, G D
AU  - Newport GD
FAU - Scallet, A C
AU  - Scallet AC
FAU - Binienda, Z
AU  - Binienda Z
FAU - Ferguson, S A
AU  - Ferguson SA
FAU - Bailey, J R
AU  - Bailey JR
FAU - Paule, M G
AU  - Paule MG
FAU - Slikker, W Jr
AU  - Slikker W Jr
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - 3,4-Methylenedioxyamphetamine/administration & dosage/*analogs & derivatives
MH  - Administration, Oral
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Brain/drug effects/metabolism
MH  - Dopamine/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Homovanillic Acid/metabolism
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Macaca mulatta
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Serotonin/*metabolism
EDAT- 1993/03/01 00:00
MHDA- 2001/03/28 10:01
CRDT- 1993/03/01 00:00
PHST- 1993/03/01 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1993/03/01 00:00 [entrez]
AID - 0892-0362(93)90067-X [pii]
AID - 10.1016/0892-0362(93)90067-x [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 1993 Mar-Apr;15(2):91-6. doi: 10.1016/0892-0362(93)90067-x.