PMID- 7685627
OWN - NLM
STAT- MEDLINE
DCOM- 19930716
LR  - 20191023
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 6
IP  - 4
DP  - 1993 Apr
TI  - Mapping the breakpoint of a constitutional translocation on chromosome 22 in a 
      patient with NF2.
PG  - 235-8
AB  - Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder characterized by 
      development of bilateral acoustic neurinomas and increased incidence of 
      meningiomas. Frequent losses of I allele of chromosome 22 in neurinomas and 
      meningiomas has indicated that the gene responsible for NF2 functions as a tumor 
      suppressor. Although the NF2 gene has been mapped within a 13 cM region between 
      D22S1 and D22S28 by linkage analysis, its location with respect to D22S15 is 
      uncertain. We previously reported an NF2 patient with a constitutional balanced 
      translocation t(4;22)(q12;q12.2); the NF2 gene is probably disrupted at the 
      breakpoint. To define the location of this breakpoint on chromosome 22, we 
      performed fluorescence in situ hybridization (FISH) with DNA markers in the NF2 
      region and determined the physical order of 5 loci: D22S1-NF2-LIF-D22S15-D22S32.
FAU - Arai, E
AU  - Arai E
AD  - Department of Biochemistry, Cancer Institute, Tokyo, Japan.
FAU - Tokino, T
AU  - Tokino T
FAU - Imai, T
AU  - Imai T
FAU - Inazawa, J
AU  - Inazawa J
FAU - Ikeuchi, T
AU  - Ikeuchi T
FAU - Tonomura, A
AU  - Tonomura A
FAU - Nakamura, Y
AU  - Nakamura Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (Genetic Markers)
SB  - IM
GS  - LIF
GS  - NF2
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 22/ultrastructure
MH  - Chromosomes, Human, Pair 4/ultrastructure
MH  - *Genes, Neurofibromatosis 2
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Molecular Sequence Data
MH  - Neurofibromatosis 2/*genetics
MH  - *Translocation, Genetic
EDAT- 1993/04/01 00:00
MHDA- 1993/04/01 00:01
CRDT- 1993/04/01 00:00
PHST- 1993/04/01 00:00 [pubmed]
PHST- 1993/04/01 00:01 [medline]
PHST- 1993/04/01 00:00 [entrez]
AID - 10.1002/gcc.2870060408 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 1993 Apr;6(4):235-8. doi: 10.1002/gcc.2870060408.