PMID- 7685864
OWN - NLM
STAT- MEDLINE
DCOM- 19930719
LR  - 20221207
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 152
IP  - 1-2
DP  - 1993 Apr 2
TI  - Effects of benzylpiperazine derivatives on the acute effects of 
      3,4-methylenedioxymethamphetamine in rat brain.
PG  - 17-20
AB  - The reduction of 5-hydroxytryptamine (5-HT) in rat brain 3 h after administration 
      of 3,4-methylenedioxymethamphetamine (MDMA) was attenuated significantly by 
      coadministration of benzylpiperazine derivatives (p-nitrobenzylpiperazine, 
      p-chlorobenzylpiperazine and 1-piperonylpiperazine), which were weak inhibitors 
      of [3H]5-HT uptake into rat brain synaptosomes. However, the coadministration of 
      desipramine and imipramine which were more potent 5-HT uptake inhibitors than 
      these benzylpiperazines, did not attenuate the reduction of 5-HT by MDMA. These 
      results suggest that these benzylpiperazines might inhibit the acute effects of 
      MDMA by a novel neuropharmacological effect other than 5-HT uptake inhibition.
FAU - Hashimoto, K
AU  - Hashimoto K
AD  - Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, 
      Japan.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Piperazines)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - OGG85SX4E4 (Imipramine)
RN  - TG537D343B (Desipramine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/antagonists & 
      inhibitors/pharmacology
MH  - Animals
MH  - Brain Chemistry/*drug effects
MH  - Desipramine/pharmacology
MH  - Hydroxyindoleacetic Acid/analysis
MH  - Imipramine/pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Piperazines/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin/*metabolism
MH  - Selective Serotonin Reuptake Inhibitors/*pharmacology
MH  - Synaptosomes/drug effects/metabolism
EDAT- 1993/04/02 00:00
MHDA- 1993/04/02 00:01
CRDT- 1993/04/02 00:00
PHST- 1993/04/02 00:00 [pubmed]
PHST- 1993/04/02 00:01 [medline]
PHST- 1993/04/02 00:00 [entrez]
AID - 0304-3940(93)90472-W [pii]
AID - 10.1016/0304-3940(93)90472-w [doi]
PST - ppublish
SO  - Neurosci Lett. 1993 Apr 2;152(1-2):17-20. doi: 10.1016/0304-3940(93)90472-w.