PMID- 7685865
OWN - NLM
STAT- MEDLINE
DCOM- 19930719
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 152
IP  - 1-2
DP  - 1993 Apr 2
TI  - Central inhibition of nitric oxide synthase preferentially augments release of 
      oxytocin during dehydration.
PG  - 190-3
AB  - Intracerebroventricular (i.c.v.) administration of NG-monomethyl-L-arginine 
      monoacetate (NMMA; 500 micrograms; 402 mM) and NG-nitro-L-arginine methyl ester 
      (NAME; 270 micrograms; 200 mM), inhibitors of nitric oxide synthase, enhanced the 
      rise in oxytocin but not vasopressin levels in plasma of conscious rats following 
      24 h of water deprivation. This effect of NMMA occurred by 10 min after 
      administration, reached its peak at 15 min and decreased by 20 min. Daily 
      administration of lower doses (50 micrograms and 0.5 microgram/5 microliter, 
      i.c.v.) of another inhibitor of nitric oxide synthase, NG-nitro-L-arginine, just 
      before and after 24 h of water deprivation and in control animals treated 
      similarly were without effect on either vasopressin or oxytocin levels. Nitric 
      oxide, therefore, attenuates preferentially the release of oxytocin during 
      dehydration.
FAU - Summy-Long, J Y
AU  - Summy-Long JY
AD  - Department of Pharmacology, M.S. Hershey Medical Center, Pennsylvania State 
      University, Hershey 17033.
FAU - Bui, V
AU  - Bui V
FAU - Mantz, S
AU  - Mantz S
FAU - Koehler, E
AU  - Koehler E
FAU - Weisz, J
AU  - Weisz J
FAU - Kadekaro, M
AU  - Kadekaro M
LA  - eng
GR  - 2RO1.NS 23055/NS/NINDS NIH HHS/United States
GR  - HD RO1-25498/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Nerve Tissue Proteins)
RN  - 11000-17-2 (Vasopressins)
RN  - 27JT06E6GR (omega-N-Methylarginine)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 50-56-6 (Oxytocin)
RN  - 94ZLA3W45F (Arginine)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 1.4.- (Amino Acid Oxidoreductases)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
SB  - IM
MH  - Amino Acid Oxidoreductases/*antagonists & inhibitors
MH  - Animals
MH  - Arginine/*analogs & derivatives/pharmacology
MH  - Dehydration/*physiopathology
MH  - Male
MH  - NG-Nitroarginine Methyl Ester
MH  - Nerve Tissue Proteins/*antagonists & inhibitors
MH  - Nitric Oxide/*metabolism
MH  - Nitric Oxide Synthase
MH  - Oxytocin/*metabolism
MH  - Paraventricular Hypothalamic Nucleus/drug effects/enzymology/metabolism
MH  - Pituitary Gland, Posterior/*drug effects/enzymology/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Supraoptic Nucleus/drug effects/enzymology/metabolism
MH  - Vasopressins/metabolism
MH  - omega-N-Methylarginine
EDAT- 1993/04/02 00:00
MHDA- 1993/04/02 00:01
CRDT- 1993/04/02 00:00
PHST- 1993/04/02 00:00 [pubmed]
PHST- 1993/04/02 00:01 [medline]
PHST- 1993/04/02 00:00 [entrez]
AID - 0304-3940(93)90515-M [pii]
AID - 10.1016/0304-3940(93)90515-m [doi]
PST - ppublish
SO  - Neurosci Lett. 1993 Apr 2;152(1-2):190-3. doi: 10.1016/0304-3940(93)90515-m.