PMID- 7686629
OWN - NLM
STAT- MEDLINE
DCOM- 19930805
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 302
IP  - 3
DP  - 1993 Jul
TI  - Micronucleus induction in mouse peripheral blood reticulocytes by 
      2,7-diaminophenazine and related compounds.
PG  - 177-82
AB  - The peripheral blood micronucleus test using acridine orange (AO) supravital 
      staining was performed with phenazine (Pz), 1-aminophenazine (1-APz), 
      2-aminophenazine (2-APz) and 2,7-diaminophenazine (2,7-DAPz). Male ICR mice and 
      BDF1 mice were treated intraperitoneally once or twice 24 h apart with each 
      chemical. Irrespective of the number of administrations, Pz and 1-APz were not 
      clastogenic in either mouse strain. In the single treatment regime, 2-APz 
      slightly increased micronucleated reticulocytes (MNRETs) 48 h after 200 mg/kg 
      dosing in ICR mice and 72 h after 400 mg/kg dosing in BDF1 mice. The MNRET 
      frequencies were not enhanced after double treatment in either mouse strain. The 
      single treatment with 2,7-DAPz strongly and dose-dependently induced MNRETs in 
      BDF1 mice, and the incidences of MNRETs, which peaked 48 or 72 h after treatment, 
      were much higher than those in ICR mice. In both mouse strains, the frequencies 
      of MNRETs observed after double treatment with 2,7-DAPz were higher than those 
      after single treatment. The MNRET incidence induced 72 h after first 200 mg/kg 
      dosing in BDF1 mice was 2.21%.
FAU - Watanabe, T
AU  - Watanabe T
AD  - Kyoto Pharmaceutical University, Japan.
FAU - Kaji, H
AU  - Kaji H
FAU - Takagi, K
AU  - Takagi K
FAU - Kinae, N
AU  - Kinae N
FAU - Hirayama, T
AU  - Hirayama T
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Mutagens)
RN  - 0 (Phenazines)
RN  - 120209-97-4 (2,7-diaminophenazine)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Micronucleus Tests
MH  - Mutagens/*toxicity
MH  - Phenazines/*toxicity
MH  - Reticulocytes/*drug effects
EDAT- 1993/07/01 00:00
MHDA- 1993/07/01 00:01
CRDT- 1993/07/01 00:00
PHST- 1993/07/01 00:00 [pubmed]
PHST- 1993/07/01 00:01 [medline]
PHST- 1993/07/01 00:00 [entrez]
AID - 0165-7992(93)90046-X [pii]
AID - 10.1016/0165-7992(93)90046-x [doi]
PST - ppublish
SO  - Mutat Res. 1993 Jul;302(3):177-82. doi: 10.1016/0165-7992(93)90046-x.