PMID- 7688094
OWN - NLM
STAT- MEDLINE
DCOM- 19930830
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 292
IP  - 1
DP  - 1993 Aug
TI  - Correlation of carcinogenic potency with mouse-skin 32P-postlabeling and 
      muta-Rmouse lac Z- mutation data for DMBA and its K-region sulphur isostere: 
      comparison with activities observed in standard genotoxicity assays.
PG  - 25-40
AB  - The genotoxicities in vitro and in vivo of the mouse-skin carcinogen 
      7,12-dimethylbenz[a]anthracene (DMBA) have been compared with those of its weakly 
      carcinogenic 4,5-sulphur analogue, 6,11-dimethylbenzo[b]naphtho-[2,3-d]thiophene 
      (S-DMBA). The only datasets that correlated with the relative carcinogenicity of 
      these agents to the skin were those conducted using topically exposed mouse skin. 
      Thus, both chemicals induced lacZ- mutations in the skin of lacZ+ transgenic 
      mice, and both produced DNA adducts on mouse-skin DNA as assessed using the 
      32P-postlabeling technique. In each case, DMBA gave a stronger response than did 
      S-DMBA. In contrast to these responses, only DMBA was active in the mouse 
      bone-marrow micronucleus assay and in the C3H10T1/2 in vitro cell transformation 
      assay. Both chemicals were mutagenic to Salmonella and of approximately equal 
      potency. The molecular geometry of DMBA and S-DMBA are compared, and divergent 
      CASE predictions of activity in the Salmonella assay and skin-painting bioassay 
      are discussed. The importance of conducting predictive genotoxicity assays in 
      systems close to those in which carcinogenicity is to be assessed is emphasized 
      by these data.
FAU - Ashby, J
AU  - Ashby J
AD  - ZENECA Central Toxicology Laboratory, Alderley Park, Macclesfield, UK.
FAU - Brusick, D
AU  - Brusick D
FAU - Myhr, B C
AU  - Myhr BC
FAU - Jones, N J
AU  - Jones NJ
FAU - Parry, J M
AU  - Parry JM
FAU - Nesnow, S
AU  - Nesnow S
FAU - Paton, D
AU  - Paton D
FAU - Tinwell, H
AU  - Tinwell H
FAU - Rosenkranz, H S
AU  - Rosenkranz HS
FAU - Curti, S
AU  - Curti S
AU  - et al.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Aniline Compounds)
RN  - 0 (Carcinogens)
RN  - 0 (Mutagens)
RN  - 0 (Phosphorus Radioisotopes)
RN  - 0 (Polycyclic Compounds)
RN  - 0 (Thiophenes)
RN  - 32362-68-8 (6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene)
RN  - 701-56-4 (N,N-dimethyl-4-anisidine)
SB  - IM
GS  - lacZ
MH  - Aniline Compounds/chemistry/*toxicity
MH  - Animals
MH  - Carcinogens/chemistry/*toxicity
MH  - Lac Operon
MH  - Male
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred CBA
MH  - Mice, Transgenic
MH  - Molecular Structure
MH  - Mutagenicity Tests
MH  - Mutagens/*toxicity
MH  - Phosphorus Radioisotopes
MH  - Polycyclic Compounds/*toxicity
MH  - Skin/drug effects
MH  - Skin Neoplasms/chemically induced
MH  - Thiophenes/*toxicity
EDAT- 1993/08/01 00:00
MHDA- 1993/08/01 00:01
CRDT- 1993/08/01 00:00
PHST- 1993/08/01 00:00 [pubmed]
PHST- 1993/08/01 00:01 [medline]
PHST- 1993/08/01 00:00 [entrez]
AID - 0165-1161(93)90005-K [pii]
AID - 10.1016/0165-1161(93)90005-k [doi]
PST - ppublish
SO  - Mutat Res. 1993 Aug;292(1):25-40. doi: 10.1016/0165-1161(93)90005-k.