PMID- 768852
OWN - NLM
STAT- MEDLINE
DCOM- 19760602
LR  - 20180216
IS  - 0030-2414 (Print)
IS  - 0030-2414 (Linking)
VI  - 32
IP  - 3-4
DP  - 1975
TI  - Nitrosourea combination chemotherapy: 1-(2-chloroethyl)-3-(4-methyl 
      cyclohexyl)-1-nitrosourea (methyl-CCNU) and cyclophosphamide.
PG  - 169-74
AB  - MCCNU and cyclophosphamide are synergistic in animal tumor systems and have 
      different chronology patterns for dose-limiting myelosuppression. The combination 
      was employed in 49 patients with metastatic cancer with each drug administered on 
      successive days and repeated at 6-week intervals. A total of 108 courses of 
      therapy were monitored, and leukopenia (WBC less than 3,000 cells/mm3) and 
      thrombocytopenia (platelets less than 150,000/mm3) were observed in 47 and 30%, 
      respectively, at nadir days 15 and 22. No clinically beneficial effects were 
      observed in 40 patients with measurable disease. Combination chemotherapy 
      employing nitrosoureas have not, as in this study, generally demonstrated 
      synergistic therapeutic effects possibly related to the low level of antitumor 
      activity of nitrosoureas in solid tumors and the use of suboptimal doses for one 
      of more agents in the combination.
FAU - Lokich, J J
AU  - Lokich JJ
FAU - Skarin, A T
AU  - Skarin AT
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Oncology
JT  - Oncology
JID - 0135054
RN  - 0 (Nitrosourea Compounds)
RN  - 684-93-5 (Methylnitrosourea)
RN  - 7BRF0Z81KG (Lomustine)
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/drug therapy
MH  - Clinical Trials as Topic
MH  - Cyclophosphamide/*therapeutic use
MH  - Drug Administration Schedule
MH  - Drug Evaluation
MH  - Drug Therapy, Combination
MH  - Female
MH  - Humans
MH  - Lomustine/therapeutic use
MH  - Lung Neoplasms/drug therapy
MH  - Male
MH  - Methylnitrosourea/therapeutic use
MH  - Middle Aged
MH  - Neoplasms/*drug therapy
MH  - Nitrosourea Compounds/*therapeutic use
MH  - Stomach Neoplasms/drug therapy
EDAT- 1975/01/01 00:00
MHDA- 1975/01/01 00:01
CRDT- 1975/01/01 00:00
PHST- 1975/01/01 00:00 [pubmed]
PHST- 1975/01/01 00:01 [medline]
PHST- 1975/01/01 00:00 [entrez]
AID - 10.1159/000225063 [doi]
PST - ppublish
SO  - Oncology. 1975;32(3-4):169-74. doi: 10.1159/000225063.